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MTOR gene

Known as: Mechanistic Target of Rapamycin (Serine/Threonine Kinase) Gene, rapamycin and FKBP12 target 1, rapamycin associated protein FRAP2 
This gene plays a role in apoptosis, cell growth, differentiation and proliferation.
National Institutes of Health

Related topics

Related topics

11 relations
Cell Proliferation Regulatory ProcessFKBP12-rapamycin associated proteinFRAP1 protein, humanPhosphorylation

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MTOR wt Allele

Papers overview

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2020
2020
Long noncoding RNA NEAT1 promotes progression of glioma as a ceRNA by sponging miR‐185‐5p to stimulate DNMT1/mTOR signaling
Long noncoding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) is regarded as an oncogene in multiple cancers. Previous… 
Review
2015
Review
2015
Programming apoptosis and autophagy with novel approaches for diabetes mellitus.
According to the World Health Organization, diabetes mellitus (DM) in the year 2030 will be ranked the seventh leading cause of… 
2013
2013
Regulation of onco and tumor suppressor MiRNAs by mTORC1 inhibitor PRP-1 in human chondrosarcoma
Metastatic chondrosarcoma of mesenchymal origin is the second most common bone malignancy and does not respond either to… 
Review
2011
Review
2011
Differing effects of rapamycin and mTOR kinase inhibitors on protein synthesis.
mTOR (mammalian target of rapamycin) forms two distinct types of complex, mTORC (mTOR complex) 1 and 2. Rapamycin inhibits some… 
Review
2005
Review
2005
The Mad 1 / Mad 2 Complex as a Template for Mad 2 Activation in the Spindle Assembly Checkpoint
The SAC monitors this process and delays anaphase until all chromosomes have attained bipolar attachment [1, 2]. Spindle… 
Highly Cited
2001
Highly Cited
2001
FRAP-p70s6K signaling is required for pancreatic cancer cell proliferation.
BACKGROUND FRAP-p70s6K signaling regulates mitogenic responses to growth factors in eukaryotic cells. Constitutive p70s6K… 
1997
1997
A Unified Total Synthesis of the Immunomodulators (−)-Rapamycin and (−)-27-Demethoxyrapamycin: Construction of the C(21−42) Perimeters
A total synthesis of the potent, naturally occurring immunomodulators (−)-rapamycin (1) and (−)-27-demethoxyrapamycin (2) has… 
Highly Cited
1995
Highly Cited
1995
Control of p70 S6 kinase by kinase activity of FRAP in vivo
the middle panel of Fig. 4d of this Letter did not print up properly. The complete figure is shown here. 
1995
1995
Structure-activity studies of rapamycin analogs: evidence that the C-7 methoxy group is part of the effector domain and positioned at the FKBP12-FRAP interface.
1989
1989
Cell cycle-dependent changes in the dynamics of MAP 2 and MAP 4 in cultured cells
To examine the behavior of microtubule-associated proteins (MAPs) in living cells, MAP 4 and MAP 2 have been derivatized with 6… 
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