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MTOR gene

Known as: Mechanistic Target of Rapamycin (Serine/Threonine Kinase) Gene, rapamycin and FKBP12 target 1, rapamycin associated protein FRAP2 
This gene plays a role in apoptosis, cell growth, differentiation and proliferation.
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
Genes encoding components of the PI3K-AKT-mTOR signaling axis are frequently mutated in cancer, but few mutations have been… Expand
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Review
2012
Review
2012
BackgroundMost targeted anticancer therapies, as well as cytotoxic and radiation therapies, are encumbered by the development of… Expand
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Highly Cited
2009
Highly Cited
2009
BackgroundmTOR signaling has been suggested to be an important factor involved in tumorigenesis, but its role in human colorectal… Expand
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Highly Cited
2007
Highly Cited
2007
TOR (Target of Rapamycin) is a highly conserved protein kinase and a central controller of cell growth. TOR is found in two… Expand
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Highly Cited
2005
Highly Cited
2005
Diffusion of a G-protein coupled receptor, mu-opioid receptor (muOR), in the plasma membrane was tracked by single-fluorescent… Expand
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Highly Cited
2004
Highly Cited
2004
Loss of PTEN function leads to activation of phosphoinositide 3-kinase (PI3K) signaling and Akt. Clinical trials are now testing… Expand
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Highly Cited
2001
Highly Cited
2001
Recent evidence places the FRAP/mTOR kinase downstream of the phosphatidyl inositol 3-kinase/Akt-signaling pathway, which is up… Expand
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Highly Cited
2000
Highly Cited
2000
The spindle checkpoint prevents errors in chromosome segregation by inhibiting anaphase onset until all chromosomes have aligned… Expand
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Highly Cited
1999
Highly Cited
1999
The multisubunit eukaryotic translation initiation factor (eIF) 4F recruits 40S ribosomal subunits to the 5' end of mRNA. The… Expand
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Highly Cited
1995
Highly Cited
1995
WHEN complexed with the intracellular protein FKBP12, rapamy-cin is a potent immunosuppressant1,2 and an inhibitor of a mitogen… Expand
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