MTOR gene

Known as: Mechanistic Target of Rapamycin (Serine/Threonine Kinase) Gene, rapamycin and FKBP12 target 1, rapamycin associated protein FRAP2 
This gene plays a role in apoptosis, cell growth, differentiation and proliferation.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1974-2018
020406019742018

Papers overview

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Highly Cited
2015
Highly Cited
2015
The TOR (target of rapamycin) kinase limits longevity by poorly understood mechanisms. Rapamycin suppresses the mammalian TORC1… (More)
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Highly Cited
2014
Highly Cited
2014
Genes encoding components of the PI3K-AKT-mTOR signaling axis are frequently mutated in cancer, but few mutations have been… (More)
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2012
2012
Inhibitors of the mammalian target of rapamycin (MTOR) belong to a family of drugs with potent immunosuppressive, antiangiogenic… (More)
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2005
2005
Differences in susceptibility to oxidative stress between males and females have been postulated. Several methods have been… (More)
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Highly Cited
2003
Highly Cited
2003
Evidence suggests that obesity may raise blood pressure (BP) through oxidative stress-sensitive mechanisms and that the Dietary… (More)
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Highly Cited
2001
Highly Cited
2001
The FKBP-12-rapamycin associated protein (FRAP, also known as mTOR and RAFT-1) is a member of the phosphoinositide kinase related… (More)
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Highly Cited
1996
Highly Cited
1996
A simple, automated test measuring the ferric reducing ability of plasma, the FRAP assay, is presented as a novel method for… (More)
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Highly Cited
1995
Highly Cited
1995
When complexed with the intracellular protein FKBP12, rapamycin is a potent immunosuppressant and an inhibitor of a mitogen… (More)
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Highly Cited
1994
Highly Cited
1994
The immunosuppressants rapamycin and FK506 bind to the same intracellular protein, the immunophilin FKBP12. The FKB12-FK506… (More)
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Highly Cited
1982
Highly Cited
1982
The evaluation of lateral diffusion coefficients of membrane components by the technique of fluorescence recovery after… (More)
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