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3-Phosphoglycerate Dehydrogenase, a Key Enzyme forl-Serine Biosynthesis, Is Preferentially Expressed in the Radial Glia/Astrocyte Lineage and Olfactory Ensheathing Glia in the Mouse Brain
TLDR
The results establish a fundamental link of the radial glia/astrocyte lineage and olfactory ensheathing glia to l-serine biosynthesis in the brain, and discuss the hypothesis that 3PGDH expression in these glia cells contributes to energy metabolism in differentiating and differentiated neurons and otherglia cells, which are known to be vulnerable to energy loss. Expand
Charged Amino Acids at the Carboxyl-Terminal Portions Determine the Intracellular Locations of Two Isoforms of Cytochromeb 5 *
TLDR
It would seem that charged amino acids in the carboxyl-terminal portion of these proteins determine their locations in the cell. Expand
N-acetylglucosamine-6-O-sulfotransferases 1 and 2 cooperatively control lymphocyte homing through L-selectin ligand biosynthesis in high endothelial venules
TLDR
The essential function of GlcNAc6ST-1 and Glcnac6 ST-2 in L-selectin ligand biosynthesis in high endothelial venules and their importance in immune surveillance are demonstrated. Expand
Critical functions of N-glycans in L-selectin-mediated lymphocyte homing and recruitment
TLDR
The results demonstrate the critical function of N-glycan-linked 6-sulfo sialyl Lewis X in L-selectin-dependent lymphocyte homing and recruitment in wild-type and mutant mice. Expand
Ceramide and Its Interconvertible Metabolite Sphingosine Function as Indispensable Lipid Factors Involved in Survival and Dendritic Differentiation of Cerebellar Purkinje Cells
TLDR
Cell‐permeable ceramide acted synergistically with the neurotrophin family, which has been previously shown to support Purkinje cell survival, and suggest that ceramide is a requisite for the survival and the dendritic differentiation ofPurkinje cells. Expand
Targeted Disruption of the Mouse 3-Phosphoglycerate Dehydrogenase Gene Causes Severe Neurodevelopmental Defects and Results in Embryonic Lethality*
TLDR
It is demonstrated that the Phgdh-dependent phosphorylated pathway is essential for normal embryonic development, especially for brain morphogenesis, using targeted gene disruption in embryonic stem cells. Expand
Extended Core 1 and Core 2 Branched O-Glycans Differentially Modulate Sialyl Lewis x-type L-selectin Ligand Activity*
TLDR
Results indicate that sialyl Lewis x in extended core 1 O-glycans can function as an L-selectin ligand and is potentially involved in neutrophil adhesion on neutrophils bound to activated endothelial cells. Expand
Induction of peripheral lymph node addressin in human gastric mucosa infected by Helicobacter pylori.
TLDR
It is shown that chronic inflammation caused by H. pylori infection is highly correlated with de novo synthesis of peripheral lymph node addressin (PNAd) presented on high-endothelial venule (HEV)-like vessels, and results suggest that PNAd in HEV-like vessels plays a critical role in lymphocyte recruitment during chronic inflammation induced by the bacterium. Expand
A novel metabolic communication between neurons and astrocytes: non-essential amino acid l-serine released from astrocytes is essential for developing hippocampal neurons
TLDR
Results strongly suggest that L-serine, released by astrocytes, is essential for the survival and phenotypic growth of hippocampal neurons. Expand
The carboxy‐terminal 10 amino acid residues of cytochrome b5 are necessary for its targeting to the endoplasmic reticulum.
TLDR
The deletion of more than 11 amino acid residues at the carboxy‐terminal end of cy tochrome b5 abolished the targeting and anchoring of the cytochrome to the ER membrane. Expand
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