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Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex
TLDR
It is shown that in Drosophila and human cells the target of rapamycin (TOR) kinase and its associated protein rictor are necessary for Ser473 phosphorylation and that a reduction in rictOr or mammalian TOR (mTOR) expression inhibited an Akt/PKB effector.
CellProfiler: image analysis software for identifying and quantifying cell phenotypes
TLDR
The first free, open-source system designed for flexible, high-throughput cell image analysis, CellProfiler is described, which can address a variety of biological questions quantitatively.
mTOR: from growth signal integration to cancer, diabetes and ageing
TLDR
Mammalian TOR complex 1 (mTORC1) and mTORC2 exert their actions by regulating other important kinases, such as S6 kinase (S6K) and Akt.
The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
TLDR
It is found that the Rag proteins—a family of four related small guanosine triphosphatases (GTPases)—interact with mTORC1 in an amino acid–sensitive manner and are necessary for the activation of the m TORC1 pathway by amino acids.
mTOR signaling at a glance
The mammalian target of rapamycin (mTOR) signaling pathway integrates both intracellular and extracellular signals and serves as a central regulator of cell metabolism, growth, proliferation and
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