T-Cell Receptor

Known as: T Cell Antigen Receptor, T-Cell Antigen Receptors, Major Histocompatibility Complex Receptor 
Heterodimeric antigen receptors present on the surface of T-cells. Two T-cell antigen receptors have been identified, consisting of heterodimeric 40… (More)
National Institutes of Health

Papers overview

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Highly Cited
2004
Highly Cited
2004
T cells infiltrating tumors have a decreased expression of signal transduction proteins, a diminished ability to proliferate, and… (More)
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Highly Cited
2001
Highly Cited
2001
Programmed death 1 (PD-1)–deficient mice develop a variety of autoimmune-like diseases, which suggests that this immunoinhibitory… (More)
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Highly Cited
2000
Highly Cited
2000
This report shows that cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) plays a key role in T cell-mediated dominant… (More)
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Highly Cited
1998
Highly Cited
1998
Peripheral tolerance may be maintained by a population of regulatory/suppressor T cells that prevent the activation of… (More)
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Highly Cited
1998
Highly Cited
1998
Despite extensive study, several of the major components involved in T cell receptor-mediated signaling remain unidentified. Here… (More)
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Highly Cited
1996
Highly Cited
1996
The requirements for T cell activation have been reported to vary widely depending on the state of the T cell, the type of… (More)
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Highly Cited
1995
Highly Cited
1995
A NUMBER of murine T-cell hybridomas undergo apoptosis within a few hours of activation by specific antigens, mitogens… (More)
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Highly Cited
1994
Highly Cited
1994
We have used organ culture of fetal thymic lobes from T cell receptor (TCR) transgenic beta 2M(-/-) mice to study the role of… (More)
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Highly Cited
1989
Highly Cited
1989
THE crucial role of the thymus in immunological tolerance1–5 has been demonstrated by establishing that T cells are positively… (More)
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Review
1988
Review
1988
The four distinct T-cell antigen receptor polypeptides (α, β, γ, δ) form two different heterodimers (α:β and γ:δ) that are very… (More)
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