T-Cell Receptor

Known as: T Cell Antigen Receptor, T-Cell Antigen Receptors, Major Histocompatibility Complex Receptor 
Heterodimeric antigen receptors present on the surface of T-cells. Two T-cell antigen receptors have been identified, consisting of heterodimeric 40… (More)
National Institutes of Health

Related topics

Related topics

22 relations

Narrower (7)

ALT-801CD19-specific chimeric antigen receptorCD8 receptorIL13-zetakine
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CD3 AntigensComplementarity Determining RegionsGene Rearrangement, T-LymphocyteGenes, T-Cell Receptor
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Broader (1)

Receptors, Antigen

Papers overview

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Highly Cited
2004
Highly Cited
2004
Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses.
T cells infiltrating tumors have a decreased expression of signal transduction proteins, a diminished ability to proliferate, and… (More)
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Highly Cited
2001
Highly Cited
2001
PD-L2 is a second ligand for PD-1 and inhibits T cell activation
Programmed death 1 (PD-1)–deficient mice develop a variety of autoimmune-like diseases, which suggests that this immunoinhibitory… (More)
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Highly Cited
2000
Highly Cited
2000
Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4
This report shows that cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) plays a key role in T cell-mediated dominant… (More)
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Highly Cited
1998
Highly Cited
1998
CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production
Peripheral tolerance may be maintained by a population of regulatory/suppressor T cells that prevent the activation of… (More)
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Highly Cited
1998
Highly Cited
1998
LAT The ZAP-70 Tyrosine Kinase Substrate that Links T Cell Receptor to Cellular Activation
Despite extensive study, several of the major components involved in T cell receptor-mediated signaling remain unidentified. Here… (More)
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Highly Cited
1996
Highly Cited
1996
T cell activation determined by T cell receptor number and tunable thresholds.
The requirements for T cell activation have been reported to vary widely depending on the state of the T cell, the type of… (More)
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Highly Cited
1995
Highly Cited
1995
Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas
A NUMBER of murine T-cell hybridomas undergo apoptosis within a few hours of activation by specific antigens, mitogens… (More)
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Highly Cited
1994
Highly Cited
1994
T cell receptor antagonist peptides induce positive selection
We have used organ culture of fetal thymic lobes from T cell receptor (TCR) transgenic beta 2M(-/-) mice to study the role of… (More)
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Highly Cited
1989
Highly Cited
1989
Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen
THE crucial role of the thymus in immunological tolerance1–5 has been demonstrated by establishing that T cells are positively… (More)
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Review
1988
Review
1988
T-cell antigen receptor genes and T-cell recognition
The four distinct T-cell antigen receptor polypeptides (α, β, γ, δ) form two different heterodimers (α:β and γ:δ) that are very… (More)
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