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let-7 Regulates Self Renewal and Tumorigenicity of Breast Cancer Cells
Let-7 regulates multiple BT-IC stem cell-like properties by silencing more than one target, and miRNA expression in self-renewing and differentiated cells from breast cancer lines and in breast T-IC and non-BT-IC from 1 degrees breast cancers is compared. Expand
Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen
A large-scale small interfering RNA screen was performed to identify host factors required by HIV-1 and more than 250 HIV-dependency factors (HDFs) were identified, suggesting that viruses evolve in host cells that optimally perform the functions required for their life cycle. Expand
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
It is shown that GSDMD-NT oligomerizes in membranes to form pores that are visible by electron microscopy and kills cell-free bacteria in vitro and may have a direct bactericidal effect within the cytosol of host cells, but the importance of direct bacterial killing in controlling in vivo infection remains to be determined. Expand
Coding-Independent Regulation of the Tumor Suppressor PTEN by Competing Endogenous mRNAs
This study identified and validated endogenous protein-coding transcripts that regulate PTEN, antagonize PI3K/AKT signaling, and possess growth- and tumor-suppressive properties and presents a road map for the prediction and validation of ceRNA activity and networks and thus imparts a trans-regulatory function to protein- coding mRNAs. Expand
The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1
1005 Human immunodeficiency virus (HIV) introduces its single-stranded RNA (ssRNA) genome into a cell in the reverse-transcription complex, which matures into the preintegration complex. This complexExpand
A phosphatase complex that dephosphorylates γH2AX regulates DNA damage checkpoint recovery
A three-protein complex containing the phosphatase Pph3 that regulates the phosphorylation status of γH2AX in vivo and efficiently dephosphorylatesγH 2AX in vitro is described. Expand
Death by a thousand cuts: granzyme pathways of programmed cell death.
This review discusses what is known about granzyme-mediated pathways of cell death as well as recent studies that implicate granzymes in immune regulation and extracellular proteolytic functions in inflammation. Expand
Tumor Suppressor NM23-H1 Is a Granzyme A-Activated DNase during CTL-Mediated Apoptosis, and the Nucleosome Assembly Protein SET Is Its Inhibitor
It is shown that GAAD is NM23-H1, a nucleoside diphosphate kinase implicated in suppression of tumor metastasis, and its specific inhibitor (IGAAD) is SET, which induces a caspase-independent cell death pathway characterized by single-stranded DNA nicks. Expand
gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair.
It is shown that protein phosphatase 2A (PP2A) is involved in removing gamma-H2AX foci from chromatin and the effect of PP2A on gamma- H2AX levels is independent of ATM, ATR, or DNA-PK activity. Expand
Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 are associated with systemic lupus erythematosus
This work reports monoallelic frameshift or missense mutations and one 3′ UTR variant of TREX1 present in 9/417 individuals with systemic lupus erythematosus but absent in 1,712 controls, and demonstrates that two mutant TREx1 alleles alter subcellular targeting. Expand