Complementarity Determining Regions

Known as: Hypervariable Region, Immunoglobulin, Regions, Complementarity-Determining, Immunoglobulin Hypervariable Regions 
Three regions (CDR1; CDR2 and CDR3) of amino acid sequence in the IMMUNOGLOBULIN VARIABLE REGION that are highly divergent. Together the CDRs from… (More)
National Institutes of Health

Related topics

Related topics

12 relations

Narrower (3)

Complementarity Determining Region 1Complementarity Determining Region 2Complementarity Determining Region 3
Immunoglobulin Heavy ChainsImmunoglobulin Light ChainsImmunoglobulin Variable RegionImmunoglobulin kappa-Chains
(More)

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas.
Noncoding RNA (ncRNA) transcripts are thought to be involved in human tumorigenesis. We report that a large fraction of genomic… (More)
Is this relevant?
Highly Cited
2005
Highly Cited
2005
Generation of high-affinity human antibodies by combining donor-derived and synthetic complementarity-determining-region diversity
Combinatorial libraries of rearranged hypervariable VH and VL sequences from nonimmunized human donors contain antigen… (More)
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Phage-displayed antibody libraries of synthetic heavy chain complementarity determining regions.
A structure-based approach was used to design libraries of synthetic heavy chain complementarity determining regions (CDRs). The… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Docking unbound proteins using shape complementarity, desolvation, and electrostatics.
A comprehensive docking study was performed on 27 distinct protein-protein complexes. For 13 test systems, docking was performed… (More)
  • table I
  • table II
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
1997
Highly Cited
1997
Electrostatic complementarity at protein/protein interfaces.
Calculation of the electrostatic potential of protein-protein complexes has led to the general assertion that protein-protein… (More)
  • figure 1
  • table 1
  • table 2
  • figure 2
  • table 3
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Isolation of picomolar affinity anti-c-erbB-2 single-chain Fv by molecular evolution of the complementarity determining regions in the center of the antibody binding site.
We determined the extent to which additional binding energy could be achieved by diversifying the complementarity determining… (More)
Is this relevant?
Highly Cited
1991
Highly Cited
1991
Identical V region amino acid sequences and segments of sequences in antibodies of different specificities. Relative contributions of VH and VL genes, minigenes, and complementarity-determining…
By examining a large database of amino acid sequences of antibodies of various specificities, we have found that many antibodies… (More)
Is this relevant?
Review
1989
Review
1989
Conformations of immunoglobulin hypervariable regions
On the basis of comparative studies of known antibody structures and sequences it has been argued that there is a small… (More)
  • table 1
  • figure 1
  • figure 2
  • table 2
  • figure 3
Is this relevant?
Highly Cited
1986
Highly Cited
1986
Replacing the complementarity-determining regions in a human antibody with those from a mouse
The variable domains of an antibody consist of a β-sheet framework with hypervariable regions (or complementarity-determining… (More)
Is this relevant?
Highly Cited
1985
Highly Cited
1985
Individual-specific ‘fingerprints’ of human DNA
Simple tandem-repetitive regions of DNA (or ‘minisatellites’) which are dispersed in the human genome frequently show substantial… (More)
Is this relevant?