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Complementarity Determining Regions

Known as: Hypervariable Region, Immunoglobulin, Regions, Complementarity-Determining, Immunoglobulin Hypervariable Regions 
Three regions (CDR1; CDR2 and CDR3) of amino acid sequence in the IMMUNOGLOBULIN VARIABLE REGION that are highly divergent. Together the CDRs from… 
National Institutes of Health

Related topics

Related topics

12 relations

Narrower (3)

Complementarity Determining Region 1Complementarity Determining Region 2Complementarity Determining Region 3
Immunoglobulin Heavy ChainsImmunoglobulin Light ChainsImmunoglobulin Variable RegionImmunoglobulin kappa-Chains

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire
Antibody repertoire diversity, potentially as high as 1011 unique molecules in a single individual, confounds characterization by… 
Highly Cited
2009
Highly Cited
2009
Epigenetic Regulation of HIV-1 Latency by Cytosine Methylation
Human immunodeficiency virus type 1 (HIV-1) persists in a latent state within resting CD4+ T cells of infected persons treated… 
Highly Cited
2005
Highly Cited
2005
Generation of high-affinity human antibodies by combining donor-derived and synthetic complementarity-determining-region diversity
Combinatorial libraries of rearranged hypervariable VH and VL sequences from nonimmunized human donors contain antigen… 
Highly Cited
2000
Highly Cited
2000
The ancestry of Brazilian mtDNA lineages.
We have analyzed 247 Brazilian mtDNAs for hypervariable segment (HVS)-I and selected restriction fragment-length-polymorphism… 
Highly Cited
1996
Highly Cited
1996
Differential expression of the 1-aminocyclopropane-1-carboxylate oxidase gene family of tomato.
The tomato ACC oxidase gene family is comprised of three members designated AC01, AC02 and AC03. These are highly homologous… 
Review
1994
Review
1994
The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement.
Highly Cited
1992
Highly Cited
1992
Antibody framework residues affecting the conformation of the hypervariable loops.
Highly Cited
1992
Highly Cited
1992
By-passing immunisation. Human antibodies from synthetic repertoires of germline VH gene segments rearranged in vitro.
Highly Cited
1991
Highly Cited
1991
Low nucleotide diversity in man.
The nucleotide diversity (pi) in humans is studied by using published cDNA and genomic sequences that have been carefully checked… 
Highly Cited
1985
Highly Cited
1985
Phosphocholine binding immunoglobulin Fab McPC603. An X-ray diffraction study at 2.7 A.
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