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Sensitivity of Human Immunodeficiency Virus Type 1 to the Fusion Inhibitor T-20 Is Modulated by Coreceptor Specificity Defined by the V3 Loop of gp120
The results of this study show that gp120-coreceptor interactions and the gp41 N-terminal heptad repeat independently contribute to sensitivity to T-20, which has important implications for the therapeutic uses of T- 20 as well as for unraveling the complex mechanisms of virus fusion and entry. Expand
The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells.
Redundant nucleophilic determinants of HIV-1 that independently permit nuclear localization of viral nucleic acids and virus replication in nondividing cells such as monocyte-derived macrophages are demonstrated. Expand
Complete nucleotide sequence of the AIDS virus, HTLV-III
The complete nucleotide sequence of two human T-cell leukaemia type III (HTLV-III) proviral DNAs each have four long open reading frames, the first two corresponding to the gag and pol genes. TheExpand
Definition, prognostic factors, treatment, and response criteria of adult T-cell leukemia-lymphoma: a proposal from an international consensus meeting.
A group of ATL researchers joined to form a consensus statement based on established data to define prognostic factors, clinical subclassifications, and treatment strategies, and a set of response criteria specific for ATL reflecting a combination of those for lymphoma and CLL was proposed. Expand
Myristoylation-dependent replication and assembly of human immunodeficiency virus 1.
  • M. Bryant, L. Ratner
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1990
Myristoylation of Pr55gag is not necessary for localization but is required for stable membrane association and assembly of HIV-1, and substitution of the myristoyl-acceptor glycine with alanine eliminates virus replication. Expand
Complete nucleotide sequences of functional clones of the AIDS virus.
The complete nucleotide sequence of the proviral form of HXB2 has now been determined and its structure is quite similar to that previously determined for HTLV-III/LAV clones whose biological capacities had not previously been demonstrated. Expand
Viral protein R regulates nuclear import of the HIV‐1 pre‐integration complex
The biochemical mechanism of Vpr function in transport of the viral pre‐integration complex to, and across, the nuclear membrane is identified. Expand
Human immunodeficiency virus type 1 viral protein R localization in infected cells and virions.
Regulation of Vpr localization may be important in the influence of this protein on virus replication in HIV-1-infected peripheral blood mononuclear cells. Expand
The sor gene of HIV-1 is required for efficient virus transmission in vitro.
The data suggest that sor influences virus replication at a novel, post-translational stage and that its action is independent of the regulatory genes tat and trs. Expand
Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I.
Exposure to the mature T-lymphocyte compartment in transgenic mice developed large granular lymphocytic leukemia, demonstrating that expression of Tax in the lymphocyte compartment is sufficient for the development of leukemia, and suggesting that human T-cell leukemia virus infection may be involved in the development. Expand