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Immunoglobulin Light Chains

Known as: Immunoglobulins, Light-Chain, Immunoglobulin Light Chains [Chemical/Ingredient], Light Chain Immunoglobulins 
Polypeptide chains, consisting of 211 to 217 amino acid residues and having a molecular weight of approximately 22 kDa. There are two major types of… 
National Institutes of Health

Related topics

Related topics

24 relations
Bence Jones ProteinBinding ProteinsComplementarity Determining RegionsGenes, Immunoglobulin Light Chain

Broader (1)

Immunologic Factors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2018
Highly Cited
2018
Immunoglobulin light chain amyloidosis: 2018 Update on diagnosis, prognosis, and treatment
Immunoglobulin light chain amyloidosis is a clonal, nonproliferative plasma cell disorder in which fragments of immunoglobulin… 
Highly Cited
2014
Highly Cited
2014
Unfolded protein response activation reduces secretion and extracellular aggregation of amyloidogenic immunoglobulin light chain
Significance Light-chain amyloidosis (AL) is a devastating human disease involving the clonal expansion of a plasma cell and the… 
Highly Cited
2013
Highly Cited
2013
Coexistent multiple myeloma or increased bone marrow plasma cells define equally high-risk populations in patients with immunoglobulin light chain amyloidosis.
PURPOSE There is consensus that patients with light chain (AL) amyloidosis with hypercalcemia, renal failure, anemia, and lytic… 
Highly Cited
2008
Highly Cited
2008
Physicochemical consequences of amino acid variations that contribute to fibril formation by immunoglobulin light chains
The most common form of systemic amyloidosis originates from antibody light chains. The large number of amino acid variations… 
Highly Cited
2001
Highly Cited
2001
Partially folded intermediates as critical precursors of light chain amyloid fibrils and amorphous aggregates.
Light chain, or AL, amyloidosis is a pathological condition arising from systemic extracellular deposition of monoclonal… 
Highly Cited
1990
Highly Cited
1990
Preferential linkage of bcl-2 to immunoglobulin light chain gene in chronic lymphocytic leukemia
Most of human follicular lymphomas possess the t(14;18) chromosome translocation that juxtaposes the IgH gene to the 3' region of… 
Highly Cited
1988
Highly Cited
1988
Herpes simplex virus regulatory elements and the immunoglobulin octamer domain bind a common factor and are both targets for virion transactivation
Highly Cited
1982
Highly Cited
1982
Correlation between immunoglobulin light chain expression and variant translocation in Burkitt's lymphoma
Burkitt's-type lymphomas–leukaemias (BL) are monoclonal proliferations of malignant B lymphocytes1. Irrespective of whether they… 
Highly Cited
1978
Highly Cited
1978
Sequence of a mouse germ-line gene for a variable region of an immunoglobulin light chain.
We have determined the sequence of the DNA of a germ-line gene for the variable region of a mouse immunoglobulin light chain, the… 
Highly Cited
1974
Highly Cited
1974
Sequence at the 3′ end of globin mRNA shows homology with immunoglobulin light chain mRNA
The sequence of 52 nucleotides adjacent to the poly(A) of rabbit β globin mRNA has been determined. Striking sequence and… 
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