• Publications
  • Influence
Genomic sequencing.
  • G. Church, W. Gilbert
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 April 1984
TLDR
The genomic sequencing procedures are applicable to the analysis of genetic polymorphisms, DNA methylation at deoxycytidines, and nucleic acid-protein interactions at single nucleotide resolution. Expand
Sequencing end-labeled DNA with base-specific chemical cleavages.
TLDR
The chapter presents techniques for producing discrete DNA fragments, end-labeling DNA, segregating end- labeled fragments, extracting DNA from gels, and the protocols for partially cleaving it at specific bases using the chemical reactions. Expand
The genetic data environment an expandable GUI for multiple sequence analysis
An X-Windows-based graphic user interface is presented which allows the seamless integration of numerous existing biomolecular programs into a single analysis environment. This environment is basedExpand
Origin of life: The RNA world
TLDR
L'auteur postule un systeme, auto-replicatif a l'origine uniquement compose de molecules d'ARN. Expand
A new method for sequencing DNA.
  • A. Maxam, W. Gilbert
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 February 1977
TLDR
Reactions that cleave DNA preferentially at guanines, at adenines,At cytosines and thymines equally, and at cytosine alone are described. Expand
Nucleotide sequence of rous sarcoma virus
TLDR
It is hypothesized that E was part of a duplicated region of over 250 nucleotides flanking the src gene in an ancestral RSV, and that differential deletion of one copy of E led to its positional difference in Pr-C and SR-A. Expand
Formation of parallel four-stranded complexes by guanine-rich motifs in DNA and its implications for meiosis
TLDR
It is speculated that this self-recognition of guanine-rich motifs of DNA serves to bring together, and to zipper up in register, the four homologous chromatids during meiosis. Expand
The evolution of spliceosomal introns: patterns, puzzles and progress
TLDR
Patterns of intron-position correspondence between widely diverged eukaryotic species have provided insights into the origins of the vast differences in intron number between eukARYotic species, and studies of specific cases of introns loss and gain have led to progress in understanding the underlying molecular mechanisms and the forces that control intron evolution. Expand
Large-scale comparison of intron positions in mammalian genes shows intron loss but no gain
TLDR
The finding of widespread conservation of intron–exon structure, even over large evolutionary distances, suggests that comparative methods employing information about gene structures should be very successful in correctly predicting exon boundaries in genomic sequences. Expand
B lineage--specific interactions of an immunoglobulin enhancer with cellular factors in vivo.
TLDR
There are changes in the reactivity of guanine residues to dimethyl sulfate within the enhancer sequence in myeloma, B, and early B cells, whereas virtually no alterations appear in cells of non-B lineage. Expand
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