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Somatomedins

Known as: Insulin-like growth factor, factor growth insulin-like, Somatomedin 
Bound to IGFBPs in the circulation, Insulin-Like Growth Factors (IGFs, Somatomedins) are a family of extracellular signaling peptides (potential… Expand
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
Stimulation of the insulin and insulin-like growth factor I (IGF-I) receptor activates the phosphoinositide-3-kinase/Akt/mTOR… Expand
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Highly Cited
2003
Highly Cited
2003
Ageing is a fundamental, unsolved mystery in biology. DAF-16, a FOXO-family transcription factor, influences the rate of ageing… Expand
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Review
2001
Review
2001
Since the original somatomedin hypothesis was conceived, a number of important discoveries have allowed investigators to modify… Expand
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Highly Cited
1997
Highly Cited
1997
BACKGROUND Protein kinase B (PKB), also known as c-Akt, is activated rapidly when mammalian cells are stimulated with insulin and… Expand
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Highly Cited
1997
Highly Cited
1997
A signaling pathway was delineated by which insulin-like growth factor 1 (IGF-1) promotes the survival of cerebellar neurons. IGF… Expand
Review
1995
Review
1995
I. Introduction THE insulin-like growth factors were discovered on the basis of their ability to stimulate cartilage sulfation… Expand
Highly Cited
1995
Highly Cited
1995
The phosphorylation of the human estrogen receptor (ER) serine residue at position 118 is required for full activity of the ER… Expand
Highly Cited
1993
Highly Cited
1993
Newborn mice homozygous for a targeted disruption of insulin-like growth factor gene (Igf-1) exhibit a growth deficiency similar… Expand
Highly Cited
1993
Highly Cited
1993
A developmental analysis of growth kinetics in mouse embryos carrying null mutations of the genes encoding insulin-like growth… Expand
Highly Cited
1993
Highly Cited
1993
THE paternal and maternal genomes are not equivalent and both are required for mammalian development1,2. The difference between… Expand