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Somatomedins

Known as: Insulin-like growth factor, factor growth insulin-like, Somatomedin 
Bound to IGFBPs in the circulation, Insulin-Like Growth Factors (IGFs, Somatomedins) are a family of extracellular signaling peptides (potential… Expand
National Institutes of Health

Related topics

Related topics

31 relations

Narrower (7)

Biomin HInsulin-Like Growth Factor IRecombinant Insulin-Like Growth Factorigf1 protein, zebrafish
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Broader (4)

Blood ProteinsGrowth FactorGrowth SubstancesNeuropeptides
Cell Proliferation Regulatory ProcessExtracellular SpaceGrowth Factor GeneInsulin-Like Growth Factor Receptor
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt.
Stimulation of the insulin and insulin-like growth factor I (IGF-I) receptor activates the phosphoinositide-3-kinase/Akt/mTOR… Expand
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Highly Cited
2003
Highly Cited
2003
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
Ageing is a fundamental, unsolved mystery in biology. DAF-16, a FOXO-family transcription factor, influences the rate of ageing… Expand
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Review
2001
Review
2001
The somatomedin hypothesis: 2001.
Since the original somatomedin hypothesis was conceived, a number of important discoveries have allowed investigators to modify… Expand
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Highly Cited
1997
Highly Cited
1997
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα
BACKGROUND Protein kinase B (PKB), also known as c-Akt, is activated rapidly when mammalian cells are stimulated with insulin and… Expand
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Highly Cited
1997
Highly Cited
1997
Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt
A signaling pathway was delineated by which insulin-like growth factor 1 (IGF-1) promotes the survival of cerebellar neurons. IGF… Expand
Review
1995
Review
1995
Insulin-like growth factors and their binding proteins: biological actions.
I. Introduction THE insulin-like growth factors were discovered on the basis of their ability to stimulate cartilage sulfation… Expand
Highly Cited
1995
Highly Cited
1995
Activation of the Estrogen Receptor Through Phosphorylation by Mitogen-Activated Protein Kinase
The phosphorylation of the human estrogen receptor (ER) serine residue at position 118 is required for full activity of the ER… Expand
Highly Cited
1993
Highly Cited
1993
Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)
Newborn mice homozygous for a targeted disruption of insulin-like growth factor gene (Igf-1) exhibit a growth deficiency similar… Expand
Highly Cited
1993
Highly Cited
1993
Role of insulin-like growth factors in embryonic and postnatal growth
A developmental analysis of growth kinetics in mouse embryos carrying null mutations of the genes encoding insulin-like growth… Expand
Highly Cited
1993
Highly Cited
1993
Role for DNA methylation in genomic imprinting
THE paternal and maternal genomes are not equivalent and both are required for mammalian development1,2. The difference between… Expand
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