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Stimulation of the insulin and insulin-like growth factor I (IGF-I) receptor activates the phosphoinositide-3-kinase/Akt/mTOR… Expand Ageing is a fundamental, unsolved mystery in biology. DAF-16, a FOXO-family transcription factor, influences the rate of ageing… Expand Since the original somatomedin hypothesis was conceived, a number of important discoveries have allowed investigators to modify… Expand BACKGROUND
Protein kinase B (PKB), also known as c-Akt, is activated rapidly when mammalian cells are stimulated with insulin and… Expand A signaling pathway was delineated by which insulin-like growth factor 1 (IGF-1) promotes the survival of cerebellar neurons. IGF… Expand I. Introduction THE insulin-like growth factors were discovered on the basis of their ability to stimulate cartilage sulfation… Expand The phosphorylation of the human estrogen receptor (ER) serine residue at position 118 is required for full activity of the ER… Expand Newborn mice homozygous for a targeted disruption of insulin-like growth factor gene (Igf-1) exhibit a growth deficiency similar… Expand A developmental analysis of growth kinetics in mouse embryos carrying null mutations of the genes encoding insulin-like growth… Expand THE paternal and maternal genomes are not equivalent and both are required for mammalian development1,2. The difference between… Expand