Somatomedins

Known as: Insulin-like growth factor, factor growth insulin-like, Somatomedin 
Bound to IGFBPs in the circulation, Insulin-Like Growth Factors (IGFs, Somatomedins) are a family of extracellular signaling peptides (potential… (More)
National Institutes of Health

Related topics

Related topics

29 relations

Narrower (7)

Biomin HInsulin-Like Growth Factor IRecombinant Insulin-Like Growth Factorigf1 protein, zebrafish
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Broader (4)

Blood ProteinsGrowth FactorGrowth SubstancesNeuropeptides
Cell Proliferation Regulatory ProcessExtracellular SpaceGrowth Factor GeneInsulin-Like Growth Factor Receptor
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Papers overview

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Review
2017
Review
2017
TFOS DEWS II Sex, Gender, and Hormones Report.
One of the most compelling features of dry eye disease (DED) is that it occurs more frequently in women than men. In fact, the… (More)
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Review
2017
Review
2017
Diagnosis and Treatment of Pituitary Adenomas: A Review.
Importance Pituitary adenomas may hypersecrete hormones or cause mass effects. Therefore, early diagnosis and treatment are… (More)
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Highly Cited
2006
Highly Cited
2006
mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt.
Stimulation of the insulin and insulin-like growth factor I (IGF-I) receptor activates the phosphoinositide-3-kinase/Akt/mTOR… (More)
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Highly Cited
2004
Highly Cited
2004
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase.
A major cause of aging is thought to result from the cumulative effects of cell loss over time. In yeast, caloric restriction (CR… (More)
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Highly Cited
2003
Highly Cited
2003
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
Ageing is a fundamental, unsolved mystery in biology. DAF-16, a FOXO-family transcription factor, influences the rate of ageing… (More)
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Highly Cited
2003
Highly Cited
2003
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
Studies in invertebrates have led to the identification of a number of genes that regulate lifespan, some of which encode… (More)
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Review
2001
Review
2001
The somatomedin hypothesis: 2001.
Since the original somatomedin hypothesis was conceived, a number of important discoveries have allowed investigators to modify… (More)
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Highly Cited
1998
Highly Cited
1998
Circulating concentrations of insulin-like growth factor I and risk of breast cancer
BACKGROUND Insulin-like growth factor (IGF)-I, a mitogenic and antiapoptotic peptide, can affect the proliferation of breast… (More)
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Highly Cited
1997
Highly Cited
1997
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα
BACKGROUND Protein kinase B (PKB), also known as c-Akt, is activated rapidly when mammalian cells are stimulated with insulin and… (More)
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Highly Cited
1993
Highly Cited
1993
Role for DNA methylation in genomic imprinting
THE paternal and maternal genomes are not equivalent and both are required for mammalian development1,2. The difference between… (More)
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