Somatomedins

Known as: Insulin-like growth factor, factor growth insulin-like, Somatomedin 
Bound to IGFBPs in the circulation, Insulin-Like Growth Factors (IGFs, Somatomedins) are a family of extracellular signaling peptides (potential… (More)
National Institutes of Health

Papers overview

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Review
2017
Review
2017
One of the most compelling features of dry eye disease (DED) is that it occurs more frequently in women than men. In fact, the… (More)
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Review
2017
Review
2017
Importance Pituitary adenomas may hypersecrete hormones or cause mass effects. Therefore, early diagnosis and treatment are… (More)
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Highly Cited
2006
Highly Cited
2006
Stimulation of the insulin and insulin-like growth factor I (IGF-I) receptor activates the phosphoinositide-3-kinase/Akt/mTOR… (More)
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Highly Cited
2004
Highly Cited
2004
A major cause of aging is thought to result from the cumulative effects of cell loss over time. In yeast, caloric restriction (CR… (More)
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Highly Cited
2003
Highly Cited
2003
Ageing is a fundamental, unsolved mystery in biology. DAF-16, a FOXO-family transcription factor, influences the rate of ageing… (More)
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Highly Cited
2003
Highly Cited
2003
Studies in invertebrates have led to the identification of a number of genes that regulate lifespan, some of which encode… (More)
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Review
2001
Review
2001
Since the original somatomedin hypothesis was conceived, a number of important discoveries have allowed investigators to modify… (More)
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Insulin-like growth factor (IGF)-I, a mitogenic and antiapoptotic peptide, can affect the proliferation of breast… (More)
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Highly Cited
1997
Highly Cited
1997
BACKGROUND Protein kinase B (PKB), also known as c-Akt, is activated rapidly when mammalian cells are stimulated with insulin and… (More)
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Highly Cited
1993
Highly Cited
1993
THE paternal and maternal genomes are not equivalent and both are required for mammalian development1,2. The difference between… (More)
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