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Somatomedins

Known as: Insulin-like growth factor, factor growth insulin-like, Somatomedin 
Bound to IGFBPs in the circulation, Insulin-Like Growth Factors (IGFs, Somatomedins) are a family of extracellular signaling peptides (potential… 
National Institutes of Health

Related topics

Related topics

31 relations

Narrower (7)

Biomin HInsulin-Like Growth Factor IRecombinant Insulin-Like Growth Factorigf1 protein, zebrafish

Broader (4)

Blood ProteinsGrowth FactorGrowth SubstancesNeuropeptides
Cell Proliferation Regulatory ProcessExtracellular SpaceGrowth Factor GeneInsulin-Like Growth Factor Receptor

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2000
Review
2000
The contradictions of the insulin-like growth factor 1 receptor
In recent years, the type 1 insulin-like growth factor receptor (IGF-IR) has emerged as a receptor that plays a very important… 
Highly Cited
1993
Highly Cited
1993
Growth Factors Prevent Mitochondrial Dysfunction, Loss of Calcium Homeostasis, and Cell Injury, but Not ATP Depletion in Hippocampal Neurons Deprived of Glucose
The mechanism of growth factor protection against metabolic/excitotoxic insults was examined. The time course of changes in ATP… 
Highly Cited
1992
Highly Cited
1992
The cytoplasmic tail of the mannose 6-phosphate/insulin-like growth factor-II receptor has two signals for lysosomal enzyme sorting in the Golgi
The mannose 6-phosphate/insulin-like growth factor-II (Man-6-P/IGF-II) receptor is known to cycle between the Golgi, endosomes… 
Highly Cited
1992
Highly Cited
1992
A His-Leu-Leu sequence near the carboxyl terminus of the cytoplasmic domain of the cation-dependent mannose 6-phosphate receptor is necessary for the lysosomal enzyme sorting function.
Highly Cited
1989
Highly Cited
1989
Nucleotide sequence and expression of a cDNA clone encoding a fetal rat binding protein for insulin-like growth factors.
Highly Cited
1988
Highly Cited
1988
Mitogenic stimulation of human breast cancer cells in a growth factor‐defined medium: Synergistic action of insulin and estrogen
The cooperative action of 17β‐estradiol (E2) and polypeptide growth factors in stimulating proliferation of human breast cancer… 
Highly Cited
1988
Highly Cited
1988
Expression of insulin-like growth factor I in transgenic mice with elevated levels of growth hormone is correlated with growth.
To study the role of insulin-like growth factor I (IGF-I) in mediating the growth-promoting function of GH, IGF-I expression was… 
Highly Cited
1985
Highly Cited
1985
Growth control of activated, synchronized murine B cells by the C3d fragment of human complement
Three restriction points control the cell cycle of activated B lymphocytes1. The first occurs directly after mitosis and is… 
Highly Cited
1981
Highly Cited
1981
Demonstration of two subtypes of insulin-like growth factor receptors by affinity cross-linking.
The structure of receptors for insulin-like growth factors in rat liver plasma membranes and the BRL 3A2 rat liver cell line has… 
Highly Cited
1981
Highly Cited
1981
Purification and primary structure of a polypeptide with multiplication-stimulating activity from rat liver cell cultures. Homology with human insulin-like growth factor II.
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