• Publications
  • Influence
Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts.
Fibroblast cell lines, designated R- and W cells, were generated, respectively, from mouse embryos homozygous for a targeted disruption of the Igf1r gene, encoding the type 1 insulin-like growthExpand
  • 519
  • 20
Insulin-like Growth Factors and Cancer
Dr. Derek LeRoith (Molecular and Cellular Physiology Section, National Institute of Diabetes and Digestive and Kidney Diseases [NIDDK], National Institutes of Health [NIH], Bethesda, Maryland): TheExpand
  • 640
  • 19
Multiple Signaling Pathways of the Insulin-Like Growth Factor 1 Receptor in Protection from Apoptosis
ABSTRACT The type 1 insulin-like growth factor receptor (IGF-1R), activated by its ligands, protects several cell types from a variety of apoptotic injuries. The main signaling pathway forExpand
  • 474
  • 18
The biology of cell reproduction
PART I: BIOLOGY 1. The Cell Cycle Phases of the cell cycle Variability of the cell cycle 2. Nondividing Cells G0 cells Terminally differentiated cells 3. Populations of Cells Stem cells TransformedExpand
  • 227
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The IGF-I receptor in cell growth, transformation and apoptosis.
  • 477
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The IGF-I receptor in cancer research.
  • R. Baserga
  • Medicine, Biology
  • Experimental cell research
  • 25 November 1999
The type 1 insulin-like growth factor receptor (IGF-IR) plays an important role in both normal and abnormal growth. It is particularly important in anchorage-independent growth. Impairment of itsExpand
  • 296
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The IGF‐1 receptor in cancer biology
The type 1 insulin‐like growth factor receptor (IGF‐1R) plays an important role in the establishment and maintenance of the transformed phenotype. It also has a strong antiapoptotic activity and hasExpand
  • 576
  • 14
The human insulin-like growth factor (IGF) binding protein-3 inhibits the growth of fibroblasts with a targeted disruption of the IGF-I receptor gene.
The insulin-like growth factors (IGFs) are important mitogens that exert their proliferative effects on cells via the type I IGF receptors (IGF-R). The IGFs also associate with IGF binding proteinsExpand
  • 306
  • 13
The insulin-like growth factor I receptor: a key to tumor growth?
  • R. Baserga
  • Biology, Medicine
  • Cancer research
  • 15 January 1995
The insulin-like growth factor I receptor (IGF-IR) belongs to the family of transmembrane tyrosine kinase receptors, like the receptors for platelet-derived growth factor, the epidermal growthExpand
  • 578
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Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor.
Fibroblast cell lines were established from mouse embryos homozygous for a targeted disruption of the Igf1r gene, encoding the type 1 receptor for insulin-like growth factor I (IGF-I) and from theirExpand
  • 539
  • 12