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Narcolepsy in orexin Knockout Mice Molecular Genetics of Sleep Regulation
TLDR
It is proposed that orexin regulates sleep/wakefulness states, and that Orexin knockout mice are a model of human narcolepsy, a disorder characterized primarily by rapid eye movement (REM) sleep dysregulation. Expand
Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo.
TLDR
Tie2-Cre transgenic mice are a new genetic tool for the analyses of endothelial cell-lineage and endothelialcell-specific gene targeting and lacZ staining in Tie2- Cre;CAG-CAT-Z embryos is consistent with endocardial-mesenchymal transformation in the atrioventricular canal and outflow tract regions. Expand
Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21.
TLDR
These findings demonstrate an unexpected role for the PPARalpha-FGF21 endocrine signaling pathway in regulating diverse metabolic and behavioral aspects of the adaptive response to starvation. Expand
Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRα
TLDR
The existence of a physiologically significant feed-forward regulatory pathway for sterol metabolism and the role of LXR alpha as the major sensor of dietary cholesterol are established. Expand
Synaptotagmin I: A major Ca2+ sensor for transmitter release at a central synapse
TLDR
It is proposed that synaptotagmin I is the major low affinity Ca2+ sensor mediating Ca2-regulation of synchronous neurotransmitter release in hippocampal neurons and not essential for asynchronous or Ca(2+)-independent release. Expand
Reeler/Disabled-like Disruption of Neuronal Migration in Knockout Mice Lacking the VLDL Receptor and ApoE Receptor 2
TLDR
It is suggested that VLDLR and ApoER2 participate in transmitting the extracellular Reelin signal to intracellular signaling processes initiated by mDab1, a cytosolic protein that activates tyrosine kinases. Expand
Synaptic assembly of the brain in the absence of neurotransmitter secretion.
TLDR
Synaptic connectivity does not depend on neurotransmitter secretion, but its maintenance does, and neurotransmitter secretion probably functions to validate already established synaptic connections. Expand
Essential functions of synapsins I and II in synaptic vesicle regulation
TLDR
Synthetic synapsins are not required for neurite outgrowth, synaptogenesis or the basic mechanics of synaptic vesicle traffic, but are essential for accelerating this traffic during repetitive stimulation. Expand
Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41
TLDR
Functional genomic, biochemical, and physiologic studies reveal that Gpr41 is a regulator of host energy balance through effects that are dependent upon the gut microbiota. Expand
Diminished Hepatic Response to Fasting/Refeeding and Liver X Receptor Agonists in Mice with Selective Deficiency of Sterol Regulatory Element-binding Protein-1c*
TLDR
Two treatments, fasting/refeeding and administration of liver X receptor (LXR) agonists, elevate the mRNA for sterol regulatory element-binding protein-1c (SREBP- 1c) and enhance lipid synthesis in liver and eliminate the exon encoding SREBP -1c from the mouse genome through homologous recombination. Expand
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