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Insulin-Like Growth Factor I

Known as: IGF-I-SmC, IGF-I, insulin like growth factor 1 
A well-characterized basic peptide believed to be secreted by the liver and to circulate in the blood. It has growth-regulating, insulin-like, and… 
National Institutes of Health

Related topics

Related topics

28 relations

Narrower (13)

Growth Factors, Combined Defect ofHumatrixIGF-I-IGFBP-3 complexIGF1 protein, human
IGF1 geneIGF1 wt AlleleInsulin-Like growth factor-I [Mass/volume] in Serum or PlasmaInsulin-Like-Growth Factor I Receptor

Broader (1)

Somatomedins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Central actions of liver-derived insulin-like growth factor I underlying its pro-cognitive effects
Increasing evidence indicates that circulating insulin-like growth factor I (IGF-I) acts as a peripheral neuroactive signal… 
Highly Cited
2006
Highly Cited
2006
Differential effects of strength training leading to failure versus not to failure on hormonal responses, strength, and muscle power gains.
The purpose of this study was to examine the efficacy of 11 wk of resistance training to failure vs. nonfailure, followed by an… 
Highly Cited
2005
Highly Cited
2005
Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor i/insulin signaling and caloric restriction.
Reduced IGF-I/insulin signaling and caloric restriction (CR) are known to extend the life span and delay age-related diseases. To… 
Highly Cited
2002
Highly Cited
2002
Myelination Is Altered in Insulin-Like Growth Factor-I Null Mutant Mice
Increasing evidence indicates that insulin-like growth factor-I (IGF-I) has an important role in oligodendrocyte development. In… 
Highly Cited
2000
Highly Cited
2000
Plasma insulin-like growth factor (IGF) I, IGF-binding protein 3, and mammographic density.
Insulin-like growth factors (IGFs) and insulin-like growth factor-binding proteins (IGFBPs) play a role in the normal development… 
Highly Cited
1996
Highly Cited
1996
Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene.
Insulin-like growth factor I (IGF-I) mediates the majority of the growth-promoting effects of growth hormone (GH) after birth.1… 
Highly Cited
1992
Highly Cited
1992
The effect of anorexia nervosa and refeeding on growth hormone-binding protein, the insulin-like growth factors (IGFs), and the IGF-binding proteins.
We studied the relationship of serum insulin-like growth factor-I (IGF-I), IGF-II, the IGF-binding proteins IGFBP-1, IGFBP-2, and… 
Highly Cited
1991
Highly Cited
1991
Serum Insulin-Like Growth Factors and Insulin-Like Growth Factor Binding Proteins in the Human Fetus. Relationships with Growth in Normal Subjects and in Subjects with Intrauterine Growth Retardation
ABSTRACT: IGF-I, IGF-II, and their binding proteins (BP) were studied in sera obtained by direct puncture of umbilical cords in… 
Highly Cited
1988
Highly Cited
1988
Expression of somatomedin/insulin-like growth factor messenger ribonucleic acids in the human fetus: identification, characterization, and tissue distribution.
Several lines of evidence indicate that multiple human fetal tissues synthesize somatomedins/insulin-like growth factors (Sm/IGFs… 
Highly Cited
1981
Highly Cited
1981
Hormonal control of immunoreactive somatomedin production by cultured human fibroblasts.
Human growth hormone (hGH) is known to be a potent stimulator of somatomedin secretion in vivo. The induction of somatomedin by… 
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