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  • Influence
Long-acting injectable risperidone: efficacy and safety of the first long-acting atypical antipsychotic.
TLDR
Long-acting injectable risperidone was efficacious and well tolerated and provides both clinicians and patients with a new mode of treatment that can improve the outcome of long-term therapy. Expand
The effect of anorexia nervosa and refeeding on growth hormone-binding protein, the insulin-like growth factors (IGFs), and the IGF-binding proteins.
TLDR
Data are consistent with the hypothesis that nutritional deprivation alters the GH-IGF axis by down-regulation of the GH receptor or its postreceptor mechanisms, and that this effect is reversible with refeeding. Expand
Low serotonin and dopamine metabolite concentrations in cerebrospinal fluid from bulimic patients with frequent binge episodes.
TLDR
Hospitalized bulimic patients with a history of binge eating more frequently than twice daily had significantly lower CSF concentrations of 5-hydroxyindoleacetic acid and homovanillic acid, and levels of both metabolites were significantly inversely correlated with binge frequency. Expand
Cerebrospinal fluid leptin in anorexia nervosa: correlation with nutritional status and potential role in resistance to weight gain.
TLDR
It is suggested that normalization of CSF leptin levels before full weight restoration during treatment of anorexic patients could contribute to resistance to weight gain and/or incomplete weight recovery. Expand
Intramuscular ziprasidone, 2 mg versus 10 mg, in the short-term management of agitated psychotic patients.
TLDR
Comparison with a study of identical design comparing 2-mg with 20-mg doses in patients with similar levels of psychopathology suggests that efficacy with 10 mg or 20 mg of ziprasidone i.m. is significant and dose related. Expand
Rapid acute treatment of agitation in individuals with schizophrenia: multicentre, randomised, placebo-controlled study of inhaled loxapine
TLDR
Inhaled loxapine provided a rapid, well-tolerated acute treatment for agitation in people with schizophrenia as assessed by primary and key secondary end-points. Expand
A double-blind comparison of valproate and lithium in the treatment of acute mania.
TLDR
Treatment with valproate alone may be particularly effective in manic patients with mixed affective states, and lithium was slightly more efficacious overall. Expand
Neuroendocrine responses to m-chlorophenylpiperazine and L-tryptophan in bulimia.
TLDR
The blunted PRL responses to m-CPP administration suggest that postsynaptic 5- HT receptor sensitivity is altered in bulimia nervosa, and that similar alterations in 5-HT receptors at or above the level of the hypothalamus may contribute to binge eating and other behavioral symptoms. Expand
CSF oxytocin in anorexia nervosa and bulimia nervosa: clinical and pathophysiologic considerations.
TLDR
The authors report that the mean CSF oxytocin level of five underweight women with restricting anorexia, but not 12 underweight bulimic anorexic women or 35 normal- Weight women with bulimia nervosa, was significantly lower than the level of 11 control subjects. Expand
Efficacy and safety of loxapine for inhalation in the treatment of agitation in patients with schizophrenia: a randomized, double-blind, placebo-controlled trial.
TLDR
Inhaled loxapine was generally safe and well tolerated and produced rapid improvement in agitated patients with psychotic disorders and may provide a rapid, well-tolerated option for treating acute psychotic agitation. Expand
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