The Endocrine System
A plethora of hormones regulate many of the body’s functions, including growth and development, metabolism, electrolyte balances, and reproduction. Numerous glands throughout the body produce…
The Endocrine Regulation of Aging by Insulin-like Signals
Despite the similarities among mammals and invertebrates in insulin-like peptides and their signal cascade, more research is needed to determine whether these signals control aging in the same way in all the species by the same mechanism.
Dwarf mice and the ageing process
The Critical Role of Metabolic Pathways in Aging
A special focus is made in this study on healthspan, as improved quality of life is the goal when translated to humans, and recent advances in the understanding of the complex role of metabolic pathways in the aging process are discussed.
Minireview: role of the growth hormone/insulin-like growth factor system in mammalian aging.
- A. Bartke
- Biology, MedicineEndocrinology
- 1 September 2005
There is considerable evidence to suggest that the genetic and endocrine mechanisms that influence aging and longevity in mice may play a similar role in other mammalian species, including the human.
Rapamycin slows aging in mice
Comment on: Anisimov VN, et al. Cell Cycle 2011; 10:4230–6
Interventions to Slow Aging in Humans: Are We Ready?
There was consensus that there is sufficient evidence that aging interventions will delay and prevent disease onset for many chronic conditions of adult and old age and their potential to be safe and effective in extending human healthspan.
Postnatal development of the Sertoli cell barrier, tubular lumen, and cytoskeleton of Sertoli and myoid cells in the rat, and their relationship to tubular fluid secretion and flow.
Data indicate that there is a temporal relationship between the development of the actin cytoskeleton within the Sertoli cell and initial formation of the SERToli cell barrier and there is also a temporal relationships between theDevelopment of theActin cytOSkeleton of myoid cells and tubular fluid flow.
Somatotropic signaling: trade-offs between growth, reproductive development, and longevity.
Results obtained in GH-related mutant mice provide striking examples of mutations of a single gene delaying aging, reducing age-related disease, and extending lifespan in a mammal and providing novel experimental systems for the study of mechanisms of aging.
Insulin-like growth factor 1 (IGF-1) and aging: Controversies and new insights
- A. Bartke, F. Dominici, D. Turyn, B. Kinney, R. Steger, J. Kopchick
- Biology, MedicineBiogerontology (Dordrecht)
It is suggested that IGF in the regulation of growth and adult body size is important in mediating the effect of longevity genes on aging and life span, and suspected mechanisms of IGF-I action in aging include reduced insulin signaling, enhanced sensitivity to insulin, and reducedthermogenesis with diminished oxidative damage of macromolecules being the likely final common pathway of these effects.