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The Endocrine System
A plethora of hormones regulate many of the body’s functions, including growth and development, metabolism, electrolyte balances, and reproduction. Numerous glands throughout the body produce… Expand
The Endocrine Regulation of Aging by Insulin-like Signals
Despite the similarities among mammals and invertebrates in insulin-like peptides and their signal cascade, more research is needed to determine whether these signals control aging in the same way in all the species by the same mechanism. Expand
Dwarf mice and the ageing process
Minireview: role of the growth hormone/insulin-like growth factor system in mammalian aging.
- A. Bartke
- Biology, Medicine
- 1 September 2005
There is considerable evidence to suggest that the genetic and endocrine mechanisms that influence aging and longevity in mice may play a similar role in other mammalian species, including the human. Expand
The Critical Role of Metabolic Pathways in Aging
A special focus is made in this study on healthspan, as improved quality of life is the goal when translated to humans, and recent advances in the understanding of the complex role of metabolic pathways in the aging process are discussed. Expand
Postnatal development of the Sertoli cell barrier, tubular lumen, and cytoskeleton of Sertoli and myoid cells in the rat, and their relationship to tubular fluid secretion and flow.
Data indicate that there is a temporal relationship between the development of the actin cytoskeleton within the Sertoli cell and initial formation of the SERToli cell barrier and there is also a temporal relationships between theDevelopment of theActin cytOSkeleton of myoid cells and tubular fluid flow. Expand
Morphometric studies on hamster testes in gonadally active and inactive states: light microscope findings.
The striking differences in the testicular structure between the active and regressed states of gonadal activity follow photoperiod-induced changes in endocrine function and suggest that the golden hamster may be used as a model to study structure-function relationships in thetestis. Expand
Interventions to Slow Aging in Humans: Are We Ready?
There was consensus that there is sufficient evidence that aging interventions will delay and prevent disease onset for many chronic conditions of adult and old age and their potential to be safe and effective in extending human healthspan. Expand
Somatotropic signaling: trade-offs between growth, reproductive development, and longevity.
Results obtained in GH-related mutant mice provide striking examples of mutations of a single gene delaying aging, reducing age-related disease, and extending lifespan in a mammal and providing novel experimental systems for the study of mechanisms of aging. Expand
Ethanol, nicotine, amphetamine, and aspartame consumption and preferences in C57BL/6 and DBA/2 mice
- Geoffrey McGlacken, R. A. Jensen, C. Meliska, A. Bartke
- Medicine, Psychology
- Pharmacology Biochemistry and Behavior
- 1 April 1995
Using a two-bottle choice paradigm, adult C57BL/6 and DBA/2 mice were given access to tapwater and an ascending series of concentrations of ethanol, nicotine, amphetamine, and th artificial sweetener, aspartame. Expand