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Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles Intracellular Aβ and Synaptic Dysfunction
Pathways towards and away from Alzheimer's disease
- M. Mattson
- Biology, PsychologyNature
- 5 August 2004
Rapid progress towards understanding the cellular and molecular alterations that are responsible for the neuron's demise may soon help in developing effective preventative and therapeutic strategies in Alzheimer's disease.
Self-Propagating, Molecular-Level Polymorphism in Alzheimer's ß-Amyloid Fibrils
Using electron microscopy and solid-state nuclear magnetic resonance measurements on fibrils formed by the 40-residue β-amyloid peptide of Alzheimer's disease (Aβ1–40), it is shown that different fibril morphologies have different underlying molecular structures, that the predominant structure can be controlled by subtle variations infibril growth conditions, and that both morphology and molecular structure are self-propagating when fibrs grow from preformed seeds.
The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women
IER is as effective as CER with regard to weight loss, insulin sensitivity and other health biomarkers, and may be offered as an alternative equivalent to CER for weight loss and reducing disease risk.
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms.
Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors
A key role for TNF in injury–induced immune response was demonstrated in TNFR–KO mice, demonstrating that drugs that target TNF signaling pathways may prove beneficial in treating stroke and traumatic brain injury.
Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease
Superoxide Flashes in Single Mitochondria
Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake
- R. Anson, Zhihong Guo, M. Mattson
- Medicine, BiologyProceedings of the National Academy of Sciences…
- 30 April 2003
In conclusion, intermittent fasting resulted in beneficial effects that met or exceeded those of caloric restriction including reduced serum glucose and insulin levels and increased resistance of neurons in the brain to excitotoxic stress in these mice.