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Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles Intracellular Aβ and Synaptic Dysfunction
TLDR
The recapitulation of salient features of AD in these mice clarifies the relationships between Abeta, synaptic dysfunction, and tangles and provides a valuable model for evaluating potential AD therapeutics as the impact on both lesions can be assessed. Expand
Pathways towards and away from Alzheimer's disease
TLDR
Rapid progress towards understanding the cellular and molecular alterations that are responsible for the neuron's demise may soon help in developing effective preventative and therapeutic strategies in Alzheimer's disease. Expand
Self-Propagating, Molecular-Level Polymorphism in Alzheimer's ß-Amyloid Fibrils
TLDR
Using electron microscopy and solid-state nuclear magnetic resonance measurements on fibrils formed by the 40-residue β-amyloid peptide of Alzheimer's disease (Aβ1–40), it is shown that different fibril morphologies have different underlying molecular structures, that the predominant structure can be controlled by subtle variations infibril growth conditions, and that both morphology and molecular structure are self-propagating when fibrs grow from preformed seeds. Expand
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
TLDR
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms. Expand
The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women
TLDR
IER is as effective as CER with regard to weight loss, insulin sensitivity and other health biomarkers, and may be offered as an alternative equivalent to CER for weight loss and reducing disease risk. Expand
Superoxide Flashes in Single Mitochondria
TLDR
It is shown that individual mitochondria undergo spontaneous bursts of superoxide generation, termed "superoxide flashes", and proposed that superoxide flashes could serve as a valuable biomarker for a wide variety of oxidative stress-related diseases. Expand
Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake
TLDR
In conclusion, intermittent fasting resulted in beneficial effects that met or exceeded those of caloric restriction including reduced serum glucose and insulin levels and increased resistance of neurons in the brain to excitotoxic stress in these mice. Expand
Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors
TLDR
A key role for TNF in injury–induced immune response was demonstrated in TNFR–KO mice, demonstrating that drugs that target TNF signaling pathways may prove beneficial in treating stroke and traumatic brain injury. Expand
Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease
TLDR
These findings suggest a sequence of events in the pathogenesis of AD in which Aβ induces membrane-associated oxidative stress, resulting in perturbed ceramide and cholesterol metabolism which, in turn, triggers a neurodegenerative cascade that leads to clinical disease. Expand
BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders
TLDR
Behavioral and pharmacological manipulations that enhance 5-HT and BDNF signaling could help promote healthy brain aging and preserve brain function during aging. Expand
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