Insulin-Like Growth Factor Receptor

Known as: Receptors, Somatomedin [Chemical/Ingredient], Receptors, Insulin-Like Growth Factors, Insulin Like Growth Factor Receptor 
Cell surface receptors that bind somatomedins and trigger intracellular changes which influence the behavior of cells. Studies have disclosed two… (More)
National Institutes of Health

Related topics

Related topics

15 relations
Cell Proliferation Regulatory ProcessGrowth Factor Receptor GenesIn BloodLigand Binding
(More)

Broader (1)

IGF1R gene

Narrower (1)

IGF1R protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
How insulin engages its primary binding site on the insulin receptor
Insulin receptor signalling has a central role in mammalian biology, regulating cellular metabolism, growth, division… (More)
Is this relevant?
Highly Cited
2012
Highly Cited
2012
The insulin receptor/insulin-like growth factor receptor family as a therapeutic target in oncology.
Over the past decade, encouraging preclinical and early clinical data concerning the relevance of the insulin receptor/insulin… (More)
  • figure 1
  • figure 2
  • table 1
Is this relevant?
Highly Cited
2008
Highly Cited
2008
A functional insulin-like growth factor receptor is not necessary for load-induced skeletal muscle hypertrophy.
Increasing the mechanical load on skeletal muscle results in increased expression of insulin-like growth factor I (IGF-I), which… (More)
Is this relevant?
Highly Cited
2007
Highly Cited
2007
Micro RNA 145 targets the insulin receptor substrate-1 and inhibits the growth of colon cancer cells.
The insulin receptor substrate-1 (IRS-1), a docking protein for both the type 1 insulin-like growth factor receptor (IGF-IR) and… (More)
Is this relevant?
Highly Cited
2005
Highly Cited
2005
A fully human recombinant IgG-like bispecific antibody to both the epidermal growth factor receptor and the insulin-like growth factor receptor for enhanced antitumor activity.
Both the epidermal growth factor receptor (EGFR) and the insulin-like growth factor receptor (IGFR) have been implicated in the… (More)
Is this relevant?
Review
2000
Review
2000
Structure and function of the type 1 insulin-like growth factor receptor
The type 1 insulin-like growth factor receptor (IGF-1R), a transmembrane tyrosine kinase, is widely expressed across many cell… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis.
The type 1 insulin-like growth factor receptor (IGF-1R), activated by its ligands, protects several cell types from a variety of… (More)
Is this relevant?
Highly Cited
1992
Highly Cited
1992
Cellular pattern of type-I insulin-like growth factor receptor gene expression during maturation of the rat brain: Comparison with insulin-like growth factors I and II
Insulin-like growth factors have a number of potent trophic effects on cultured neural tissue and most if not all of these… (More)
Is this relevant?
Highly Cited
1991
Highly Cited
1991
Insulin-like growth factors (IGFs), IGF receptors, and IGF-binding proteins in primary cultures of prostate epithelial cells.
Insulin-like growth factors (IGFs) are potent mitogens that bind with high affinity and specificity to IGF receptors and IGF… (More)
Is this relevant?
Review
1989
Review
1989
Insulin and insulin-like growth factor receptors in the nervous system
Insulin and the insulin-like growth factors (I and II) are homologous peptides essential to normal metabolism as well as growth… (More)
  • table 1
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?