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Insulin-Like Growth Factor Receptor

Known as: Receptors, Somatomedin [Chemical/Ingredient], Receptors, Insulin-Like Growth Factors, Insulin Like Growth Factor Receptor 
Cell surface receptors that bind somatomedins and trigger intracellular changes which influence the behavior of cells. Studies have disclosed two… 
National Institutes of Health

Related topics

Related topics

15 relations
Cell Proliferation Regulatory ProcessGrowth Factor Receptor GenesIn BloodLigand Binding

Broader (1)

IGF1R gene

Narrower (1)

IGF1R protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2013
Review
2013
Recent advancements in small molecule inhibitors of insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase as anticancer agents.
Advancements in understanding of the genetics, genomics, biochemistry and the pharmacology of cancer inhuman, have driven the… 
Review
2010
Review
2010
Effect of type 1 insulin-like growth factor receptor targeted therapy on chemotherapy in human cancer and the mechanisms involved
IntroductionChemotherapy is administered only to patients with advanced cancers, typically to modest avail. Hence, the search for… 
Review
2008
Review
2008
Targeting the type 1 insulin-like growth factor receptor as a treatment for cancer
Background: The type 1 insulin-like growth factor receptor (IGF1R) plays a critical role in transformation, invasion and… 
2006
2006
Model for the complex between the insulin-like growth factor I and its receptor: towards designing antagonists for the IGF-1 receptor.
  • V. EpaC. Ward
  • Protein engineering, design & selection : PEDS
  • 2006
  • Corpus ID: 6697274
The type-1 insulin-like growth factor receptor (IGF-1R) is the cognate tyrosine kinase receptor for the insulin-like growth… 
2003
2003
Resistance to different antiestrogens is caused by different multi-factorial changes and is associated with reduced expression of IGF receptor Ialpha.
Development of antiestrogen resistance is a major clinical problem, and therefore it is crucial to elucidate the mechanisms… 
2000
2000
IGF-I stimulates chemotaxis of human neuroblasts. Involvement of type 1 IGF receptor, IGF binding proteins, phosphatidylinositol-3 kinase pathway and plasmin system.
SH-SY5Y human neuroblastoma cells express IGF receptors, IGFs and IGF binding proteins (IGFBPs), and provide a model for studying… 
1996
1996
Insulin-like growth factor I (IGF-I), IGF-II and type-I IGF receptor gene expression in the ovary of the laying hen.
Expression of genes encoding insulin-like growth factor I (IGF-I), insulin-like growth factor II (IGF-II) and type I insulin-like… 
Highly Cited
1989
Highly Cited
1989
Biotechnology in Growth Regulation
1989
1989
Dexamethasone effects on creatine kinase activity and insulin‐like growth factor receptors in cultured muscle cells
We examined the effects of dexamethasone on creatine kinase (CK) activity and insulin‐like growth factor I (IGF‐I) binding in two… 
Highly Cited
1976
Highly Cited
1976
Somatomedin-C receptor ontogeny and levels in porcine fetal and human cord serum.
The ontogeny of somatomedin receptors in tissues of fetal pigs and levels of somatomedin-C in fetal pig serum at various… 
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