Mechanisms of regulation of cell adhesion and motility by insulin receptor substrate-1 in prostate cancer cells

@article{Reiss2001MechanismsOR,
  title={Mechanisms of regulation of cell adhesion and motility by insulin receptor substrate-1 in prostate cancer cells},
  author={Krzysztof Reiss and J Wang and Gaetano Romano and Xiao Tu and Francesca Peruzzi and Renato Baserga},
  journal={Oncogene},
  year={2001},
  volume={20},
  pages={490-500}
}
LNCaP cells are human prostatic cancer cells that have a frame-shift mutation of the tumor suppressor gene PTEN and do not express the insulin receptor substrate-1 (IRS-1), a major substrate of the type 1 insulin-like growth factor receptor (IGF-IR). Ectopic expression of IRS-1 in LNCaP cells increases cell adhesion and decreases cell motility by an IGF-I-independent mechanism. We show now that these effects of IRS-1 are accompanied by serine phosphorylation of IRS-1 and are inhibited by… CONTINUE READING

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