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S1PR3 gene

Known as: S1P3, Sphingosine-1-Phosphate Receptor 3 Gene, ENDOTHELIAL DIFFERENTIATION GENE 3 
This gene encodes a G protein-coupled receptor that may play a role in the regulation of angiogenesis and vascular endothelial cell function.
National Institutes of Health

Related topics

Related topics

10 relations
G Protein-Coupled Receptor SignalingLigand BindingPhospholipid BindingReceptor Signaling

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S1PR3 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Population of sensory neurons essential for asthmatic hyperreactivity of inflamed airways
Significance Asthma is an inflammatory airway disease characterized by acute attacks in which airway constriction impedes… 
Highly Cited
2014
Highly Cited
2014
DNA methylation and mRNA and microRNA expression of SLE CD4+ T cells correlate with disease phenotype.
Highly Cited
2012
Highly Cited
2012
Sphingosine-1-phosphate receptor-3 is a novel biomarker in acute lung injury.
The inflamed lung exhibits oxidative and nitrative modifications of multiple target proteins, potentially reflecting disease… 
Highly Cited
2010
Highly Cited
2010
S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species.
AIMS Sphingosine kinase 1 (SPHK1), its product sphingosine-1-phosphate (S1P), and S1P receptor subtypes have been suggested to… 
Highly Cited
2005
Highly Cited
2005
Discovery of potent 3,5-diphenyl-1,2,4-oxadiazole sphingosine-1-phosphate-1 (S1P1) receptor agonists with exceptional selectivity against S1P2 and S1P3.
A class of 3,5-diphenyl-1,2,4-oxadiazole based compounds have been identified as potent sphingosine-1-phosphate-1 (S1P1) receptor… 
Highly Cited
2002
Highly Cited
2002
Cell Type-specific Localization of Human Cardiac S1P Receptors
Sphingosine 1-phosphate (S1P), which derives from the metabolism of sphingomyelin, is mainly synthesized, stored, and released… 
Highly Cited
1999
Highly Cited
1999
Differential Pharmacological Properties and Signal Transduction of the Sphingosine 1-Phosphate Receptors EDG-1, EDG-3, and EDG-5*
Sphingosine 1-phosphate (SPP) is a potent lipid mediator released upon cellular activation. In this report, pharmacological… 
Highly Cited
1999
Highly Cited
1999
Lysophosphatidic acid and sphingosine 1-phosphate protection of T cells from apoptosis in association with suppression of Bax.
Members of a subfamily of G protein-coupled receptors (GPCRs), encoded by five different endothelial differentiation genes (edgs… 
Highly Cited
1999
Highly Cited
1999
EDG3 is a functional receptor specific for sphingosine 1-phosphate and sphingosylphosphorylcholine with signaling characteristics distinct from EDG1 and AGR16.
AGR16/H218/EDG5 and EDG1 are functional receptors for lysosphingolipids, whereas EDG2 and EGD4 are receptors for lysophosphatidic… 
Highly Cited
1996
Highly Cited
1996
Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9.
A novel human GPCR gene was cloned by PCR with degenerate primers designed from cannabinoid type 1 receptor (CB1) sequences and a… 
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