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Activation of R-Ras by Ras-Guanine Nucleotide-releasing Factor*
Findings raise the possibility that R-Ras is activated by Ras-GRF in brain and testis, and by C3G in other tissues, respectively, according to the guanine nucleotide-releasing activities of Ras- GRF, mSos, and C3g.
Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice.
It is shown that intact Mob1a or Mob1b is essential for murine embryogenesis and that loss of the remaining WT Mob1 allele inMob1a(Δ/Δ)1b(tr/+) or Mob2a(tr/tr) mice results in tumor development, and MOB1A and Mob1B have overlapping functions in skin homeostasis and exert their roles as tumor suppressors by regulating downstream elements of the Hippo pathway.
Role of oxidative stress in germ cell apoptosis induced by di(2-ethylhexyl)phthalate.
Results indicate that oxidative stress elicited by MEHP principally injured mitochondrial function and induced the release of cytochrome c, thereby inducing apoptosis of spermatocytes and causing atrophy of the testis.
Induction of indoleamine 2,3-dioxygenase in mouse lung during virus infection.
- R. Yoshida, Y. Urade, M. Tokuda, O. Hayaishi
- Biology, MedicineProceedings of the National Academy of Sciences…
- 1 August 1979
Indoleamine 2,3-dioxygenase activity in the supernatant fraction of mouse lung homogenate increased approximately 120-fold after infection with PR8 influenza virus, and appeared to be closely related to the infiltrations of mononuclear and lymphocytic cells.
Izumoring: a novel and complete strategy for bioproduction of rare sugars.
The role of artificial and natural sweeteners in reducing the consumption of table sugar: A narrative review.
Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9.
- F. Yamaguchi, M. Tokuda, O. Hatase, S. Brenner
- BiologyBiochemical and biophysical research…
- 14 October 1996
A novel human GPCR gene was cloned by PCR with degenerate primers designed from cannabinoid type 1 receptor sequences and a full-length clone was isolated by screening of a human genomic DNA library and showed that a 2.8 kb transcript of EDG-3 is abundantly expressed in the heart followed by placenta, kidney and liver.
Conformational changes induced by binding of divalent cations to calregulin.
Of 12 cations tested, only Zn2+ and Ca2+ produced changes in calregulin intrinsic fluorescence, and none of these metal ions could inhibit or mimic the Zn 2+-induced blue shift in ANS emission maximum.
Study on the Postprandial Blood Glucose Suppression Effect of D-Psicose in Borderline Diabetes and the Safety of Long-Term Ingestion by Normal Human Subjects
The results suggest that D-psicose had an effect to suppress the postprandial blood glucose elevation mainly in borderline diabetes cases.
Survivin expression and its correlation with cell proliferation and prognosis in epithelial ovarian tumors.
- L. Sui, Youyi Dong, M. Ohno, Yasuo Watanabe, K. Sugimoto, M. Tokuda
- MedicineInternational journal of oncology
- 1 August 2002
The findings suggest that survivin overexpression may play a pivotal role in the progression of ovarian tumors and may provide an important prognostic implication for epithelial ovarian carcinomas.