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The cAMP Transduction Cascade Mediates the Prostaglandin E2 Enhancement of the Capsaicin-Elicited Current in Rat Sensory Neurons: Whole-Cell and Single-Channel Studies
TLDR
Modulation of the capsaicin-gated channel by the cAMP–protein kinase A signaling pathway enhanced the gating of these channels and consequently resulted in the sensitization of the whole-cell currents. Expand
Activation of Epidermal Vanilloid Receptor-1 Induces Release of Proinflammatory Mediators in Human Keratinocytes
TLDR
The results suggest that VR1 expression in keratinocytes may have a role in the inflammation that occurs secondary to epidermal damage or insult, and thus may function as a sensor for noxious cutaneous stimulation. Expand
The cAMP transduction cascade mediates the PGE2‐induced inhibition of potassium currents in rat sensory neurones
TLDR
PGE2 inhibits an outward IK in sensory neurones via activation of PKA and are consistent with the idea that the PGE2‐mediated sensitization of sensory neurone results, in part, from an inhibition of delayed rectifier‐like IK. Expand
Prostaglandins suppress an outward potassium current in embryonic rat sensory neurons.
TLDR
The results suggest that pro-inflammatory prostaglandins enhance the excitability of rat sensory neurons, in part, through the suppression of an outward potassium current that may modulate the firing threshold for generation of the action potential. Expand
Ceramide, a putative second messenger for nerve growth factor, modulates the TTX‐resistant Na+ current and delayed rectifier K+ current in rat sensory neurons
TLDR
The findings indicate that the pro‐inflammatory agent, NGF, can rapidly enhance the excitability of sensory neurons. Expand
Unraveling the story of NGF-mediated sensitization of nociceptive sensory neurons: ON or OFF the Trks?
TLDR
Contrary to the general consensus, both NGF receptors appear to contribute to peripheral sensitization although whether they act independently or together remains to be determined. Expand
Tumor Necrosis Factor Enhances the Capsaicin Sensitivity of Rat Sensory Neurons
TLDR
Results indicate that TNFα can enhance the sensitivity of sensory neurons to the excitation produced by capsaicin and that this enhancement likely is mediated by the neuronal production of prostaglandins. Expand
Regulation of N-type voltage-gated calcium channels (Cav2.2) and transmitter release by collapsin response mediator protein-2 (CRMP-2) in sensory neurons
TLDR
A novel role for CRMP-2 in the regulation of N-type Ca2+ channels and in transmitter release is found and is supported by co-immunoprecipitation experiments. Expand
Differential regulation of evoked peptide release by voltage-sensitive calcium channels in rat sensory neurons
TLDR
The results indicate that the sensitizing actions of PGE2 as measured by enhanced peptide release, are not mediated by L-, N-, or P-type VSCC. Expand
Tumor necrosis factor α and interleukin-1β stimulate the expression of cyclooxygenase II but do not alter prostaglandin E2 receptor mRNA levels in cultured dorsal root ganglia cells
TLDR
Results indicate that TNFα and IL‐1β induce the functional expression of COX‐2 but not EP receptors in DRG cells in culture and suggest that cytokine‐induced sensitization of sensory neurons is secondary to prostaglandin production and not alterations in EP receptors. Expand
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