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G Protein-Coupled Receptor Signaling

Known as: G Protein Coupled Receptor Signaling, G-Protein Coupled Receptor Signaling, GPCR Signaling 
A cellular process that initiates with the binding of a G protein-associated transmembrane receptor to its cognate ligand,and results in a specific… 
National Institutes of Health

Related topics

Related topics

50 relations
ACKR4 geneADGRE1 geneADORA2A protein, humanADORA2B gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
NF1 Is a Direct G Protein Effector Essential for Opioid Signaling to Ras in the Striatum
Review
2016
Review
2016
RGS proteins as targets in the treatment of intestinal inflammation and visceral pain: New insights and future perspectives
Regulators of G protein signaling (RGS) proteins provide timely termination of G protein‐coupled receptor (GPCR) responses… 
Review
2016
Review
2016
G-protein coupled receptors: advances in simulation and drug discovery.
Review
2013
Review
2013
Interactions of the α-subunits of heterotrimeric G-proteins with GPCRs, effectors and RGS proteins: a critical review and analysis of interacting surfaces, conformational shifts, structural diversity…
2012
2012
RGS Proteins in Heart: Brakes on the Vagus
It has been nearly a century since Otto Loewi discovered that acetylcholine (ACh) release from the vagus produces bradycardia and… 
Highly Cited
2011
Highly Cited
2011
Distinct Phosphorylation Sites on the β2-Adrenergic Receptor Establish a Barcode That Encodes Differential Functions of β-Arrestin
Different patterns of GPCR phosphorylation produce distinct conformations of β-arrestin and specific downstream responses… 
Highly Cited
2010
Highly Cited
2010
σ1 Receptor Modulation of G-Protein-Coupled Receptor Signaling: Potentiation of Opioid Transduction Independent from Receptor Binding
σ Ligands modulate opioid actions in vivo, with agonists diminishing morphine analgesia and antagonists enhancing the response… 
Highly Cited
2008
Highly Cited
2008
Haloperidol and Clozapine Differentially Affect the Expression of Arrestins, Receptor Kinases, and Extracellular Signal-Regulated Kinase Activation
Dopamine and other G protein-coupled receptors (GPCRs) represent the major target of antipsychotic drugs. GPCRs undergo… 
Review
2006
Review
2006
Regulation of G Protein-Coupled Receptor Signaling by A-Kinase Anchoring Proteins
Specificity of transduction events is controlled at the molecular level by scaffold, anchoring, and adaptor proteins, which… 
Highly Cited
1997
Highly Cited
1997
A β-Arrestin/Green Fluorescent Protein Biosensor for Detecting G Protein-coupled Receptor Activation*
G protein-coupled receptors (GPCR) represent the single most important drug targets for medical therapy, and information from… 
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