G Protein-Coupled Receptor Signaling
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It is well recognized that G-protein-coupled receptors (GPCRs) can activate Ras-regulated kinase pathways to produce lasting… Expand Regulators of G protein signaling (RGS) proteins provide timely termination of G protein‐coupled receptor (GPCR) responses… Expand G-protein coupled receptors (GPCRs), the largest family of human membrane proteins, mediate cellular signaling and represent… Expand G-protein coupled receptors (GPCRs) are one of the largest families of membrane receptors in eukaryotes. Heterotrimeric G… Expand It has been nearly a century since Otto Loewi discovered that acetylcholine (ACh) release from the vagus produces bradycardia and… Expand Different patterns of GPCR phosphorylation produce distinct conformations of β-arrestin and specific downstream responses… Expand σ Ligands modulate opioid actions in vivo, with agonists diminishing morphine analgesia and antagonists enhancing the response… Expand Dopamine and other G protein-coupled receptors (GPCRs) represent the major target of antipsychotic drugs. GPCRs undergo… Expand Specificity of transduction events is controlled at the molecular level by scaffold, anchoring, and adaptor proteins, which… Expand G protein-coupled receptors (GPCR) represent the single most important drug targets for medical therapy, and information from… Expand