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ADORA2B gene

Known as: ADORA2B, A2BR, ADENOSINE A2B RECEPTOR 
This gene plays a regulatory role in the enzymatic activity of adenylate cyclase and axon elongation.
National Institutes of Health

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ADORA2A geneADORA2A protein, humanADORA2A wt AlleleADORA2B protein, human

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ADORA2B wt Allele

Papers overview

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2018
2018
Understanding the Role of Adenosine A2AR Heteroreceptor Complexes in Neurodegeneration and Neuroinflammation
Adenosine is a nucleoside mainly formed by degradation of ATP, located intracellularly or extracellularly, and acts as a… 
Highly Cited
2017
Highly Cited
2017
HIF1A up‐regulates the ADORA2B receptor on alternatively activated macrophages and contributes to pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a deadly chronic lung disease. Extracellular accumulation of adenosine and subsequent… 
Highly Cited
2015
Highly Cited
2015
Deletion of ADORA2B from myeloid cells dampens lung fibrosis and pulmonary hypertension
Idiopathic pulmonary fibrosis (IPF) is a lethal, fibroproliferative disease. Pulmonary hypertension (PH) can develop secondary to… 
Highly Cited
2015
Highly Cited
2015
Adenosine A2b receptor promotes progression of human oral cancer
BackgroundAdenosine A2b receptor (ADORA2B) encodes an adenosine receptor that is a member of the G protein-coupled receptor… 
Highly Cited
2013
Highly Cited
2013
Elevated Ecto-5'-nucleotidase-Mediated Increased Renal Adenosine Signaling Via A2B Adenosine Receptor Contributes to Chronic Hypertension
Rationale: Hypertension is the most prevalent life-threatening disease worldwide and is frequently associated with chronic kidney… 
2012
2012
Adora2b Signaling on Bone Marrow Derived Cells Dampens Myocardial Ischemia-Reperfusion Injury
Background: Cardiac ischemia-reperfusion (I-R) injury represents a major cause of cardiac tissue injury. Adenosine signaling… 
2009
2009
Adenosine A2B receptors are highly expressed on murine type II alveolar epithelial cells.
The adenosine A(2B) receptor (A(2B)R) has a wide tissue distribution that includes fibroblasts and endothelial and epithelial… 
Highly Cited
2004
Highly Cited
2004
Functional effects of enhancing or silencing adenosine A2b receptors in cardiac fibroblasts.
Cardiac fibroblasts (CF) express adenosine (ADO) receptors, and pharmacological evidence suggests the possible involvement of the… 
Highly Cited
2001
Highly Cited
2001
Adenosine A2B receptors behave as an alternative anchoring protein for cell surface adenosine deaminase in lymphocytes and cultured cells.
Adenosine deaminase (ADA) is an enzyme of the purine metabolism that has been largely considered to be cytosolic. Recently, it… 
Highly Cited
2001
Highly Cited
2001
Differential gene expression of adenosine A1, A2a, A2b, and A3 receptors in the human enteric nervous system
Adenosine receptors (ADORs) in the enteric nervous system may be of importance in the control of motor and secretomotor functions… 
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