S. Brenner

Publications206
h-index74
Citations30,930
Highly Influential Citations1,834
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The structure of the nervous system of the nematode Caenorhabditis elegans.
The structure and connectivity of the nervous system of the nematode Caenorhabditis elegans has been deduced from reconstructions of electron micrographs of serial sections. The hermaphrodite nervous…
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The genetics of Caenorhabditis elegans.
TLDR
Estimates of the induced mutation frequency of both the visible mutants and X chromosome lethals suggests that, just as in Drosophila, the genetic units in C. elegans are large.
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The neural circuit for touch sensitivity in Caenorhabditis elegans
TLDR
This analysis revealed that there are two pathways for touch-mediated movement for anterior touch (through the AVD and AVB interneurons) and a single pathway for posterior touch (via the PVC interneures) and that stimulation of these receptors may modify a number of behaviors.
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Nondisjunction Mutants of the Nematode CAENORHABDITIS ELEGANS.
TLDR
The frequency of males among the self progeny of wild-type Caenorhabditis elegans hermaphrodites (5AA; XX) is about one in 500, and fifteen him mutations have been identified that increase this frequency by a factor of ten to 150, as a result of increased X-chromosome nondisjunction.
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Whole-Genome Shotgun Assembly and Analysis of the Genome of Fugu rubripes
The compact genome of Fugu rubripes has been sequenced to over 95% coverage, and more than 80% of the assembly is in multigene-sized scaffolds. In this 365-megabase vertebrate genome, repetitive DNA…
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Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbx
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The structure of the ventral nerve cord of Caenorhabditis elegans.
TLDR
The nervous system of Caenorhabditis elegans is arranged as a series of fibre bundles which run along internal hypodermal ridges and three of the motor neurone classes receive their synaptic input from a set of interneurones coming from the nerve ring.
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Integrative genome‐wide analysis reveals cooperative regulation of alternative splicing by hnRNP proteins
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Distinct cis-essential modules direct the time-space pattern of the Pax6 gene activity.
TLDR
A structural and functional conservation of the Pax6 regulatory elements in the vertebrate genome is indicated and Corresponding regulatory elements from pufferfish are able to mimic the reporter expression in transgenic mice.
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Elephant shark genome provides unique insights into gnathostome evolution
TLDR
The whole-genome analysis of a cartilaginous fish, the elephant shark (Callorhinchus milii), finds that the C. milii genome is the slowest evolving of all known vertebrates, and features extensive synteny conservation with tetrapod genomes, making it a good model for comparative analyses of gnathostome genomes.
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