Receptor Signaling

An intercellular process that involves a cellular receptor binding to a cognate ligand and results in a specific cellular response.
National Institutes of Health

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ADGRE1 geneADORA2B protein, humanADRB1 geneARMET protein, human
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Papers overview

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Highly Cited
2007
Highly Cited
2007
Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling.
Cryopyrin is essential for caspase-1 activation triggered by Toll-like receptor (TLR) ligands in the presence of adenosine… (More)
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Highly Cited
2006
Highly Cited
2006
Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling.
Innate immune signals mediated by Toll-like receptors (TLRs) have been thought to contribute considerably to the antibody… (More)
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Highly Cited
2005
Highly Cited
2005
IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines.
Cytokines of the interleukin-1 (IL-1) family, such as IL-1 alpha/beta and IL-18, have important functions in host defense, immune… (More)
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Review
2004
Review
2004
Leptin receptor signaling and the regulation of mammalian physiology.
While the hormone leptin and its receptor were discovered relatively recently, a great deal is already known about the molecular… (More)
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Highly Cited
2003
Highly Cited
2003
Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF…
We previously reported a new Toll/IL-1R (TIR)-containing molecule, named TIR domain-containing adaptor inducing IFN-beta (TRIF… (More)
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Highly Cited
2003
Highly Cited
2003
SIGIRR, a negative regulator of Toll-like receptor–interleukin 1 receptor signaling
The Toll-like receptor–interleukin 1 receptor signaling (TLR–IL-1R) receptor superfamily is important in differentially… (More)
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Highly Cited
2002
Highly Cited
2002
Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling.
MyD88 is a Toll/IL-1 receptor (TIR) domain-containing adapter common to signaling pathways via Toll-like receptor (TLR) family… (More)
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Highly Cited
2001
Highly Cited
2001
Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells.
Heat shock proteins (HSPs) require no adjuvant to confer immunogenicity to bound peptides, as if they possessed an intrinsic… (More)
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Highly Cited
1996
Highly Cited
1996
Control of EGF receptor signaling by clathrin-mediated endocytosis.
Epidermal growth factor receptor (EGFR) signaling was analyzed in mammalian cells conditionally defective for receptor-mediated… (More)
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Highly Cited
1995
Highly Cited
1995
Kinetic proofreading in T-cell receptor signal transduction.
  • T. Mckeithan
  • Proceedings of the National Academy of Sciences…
  • 1995
Like other cell-surface receptors with intrinsic or associated protein-tyrosine kinase activity, the T-cell receptor complex… (More)
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