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Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition
Characterization of the two COX isozymes is allowing the discrimination of the roles each play in physiological processes such as homeostatic maintenance of the gastrointestinal tract, renal function, blood clotting, embryonic implantation, parturition, pain, and fever. Expand
Human cyclooxygenase-2 cDNA.
  • T. Hla, K. Neilson
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 15 August 1992
High-level induction of the hCox-2 transcript in mesenchymal-derived inflammatory cells suggests a role in inflammatory conditions and demonstrates that the Cox enzyme is encoded by at least two genes that are expressed and differentially regulated in a variety of cell types. Expand
Vascular Endothelial Cell Adherens Junction Assembly and Morphogenesis Induced by Sphingosine-1-Phosphate
It is shown that sphingosine-1-phosphate (SPP), a platelet-derived bioactive lipid, activates the EDG-1 and -3 subtypes of G protein-coupled receptors on endothelial cells to regulate angiogenesis. Expand
Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation.
  • Y. Liu, R. Wada, +11 authors R. Proia
  • Biology, Medicine
  • The Journal of clinical investigation
  • 15 October 2000
The data reveal Edg-1 to be the first G protein-coupled receptor required for blood vessel formation and show that sphingolipid signaling is essential during mammalian development. Expand
Regulation of PTEN by Rho small GTPases
It is shown that RhoA and Cdc42, members of the Rho family of small GTPases, regulate the intracellular localization of PTEN in leukocytes and human transfected embryonic kidney cells, and that small G TPase-mediated regulation of PT EN has a significant role in the regulation of chemotaxis. Expand
Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M
It is shown that HDL-associated S1P is bound specifically to both human and murine apolipoprotein M (apoM), and apoM, by delivering S 1P to the S1p1 receptor on endothelial cells, is a vasculoprotective constituent of HDL. Expand
Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1.
Overexpression of EDG-1 induced exaggerated cell-cell aggregation, enhanced expression of cadherins, and formation of well-developed adherens junctions in a manner dependent on SPP and the small guanine nucleotide binding protein Rho. Expand
Characterization of a Novel Sphingosine 1-Phosphate Receptor, Edg-8*
The cloned and characterized Edg-8 is a high affinity sphingosine 1-phosphate receptor that couples to Gi/oα proteins and is expressed predominantly by oligodendrocytes and/or fibrous astroCytes in the rat brain. Expand
Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors.
  • M. Kluk, T. Hla
  • Biology, Medicine
  • Biochimica et biophysica acta
  • 23 May 2002
The current state of knowledge of the expression patterns, signaling pathways and functional characteristics of the different S1P receptors are reviewed to improve the understanding of cardiovascular development as well as vascular diseases and may lead to novel therapeutic approaches. Expand
Differential Coupling of the Sphingosine 1-Phosphate Receptors Edg-1, Edg-3, and H218/Edg-5 to the Gi, Gq, and G12 Families of Heterotrimeric G Proteins*
These studies represent the first characterization of S1P receptor activity through G proteins directly and establish fundamental differences in coupling. Expand