A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury
A molecular explanation why SARS-CoV infections cause severe and often lethal lung failure and suggest a rational therapy for SARS and possibly other respiratory disease viruses is provided.
Molecular characterization of mitochondrial apoptosis-inducing factor
The identification and cloning of an apoptosis-inducing factor, AIF, which is sufficient to induce apoptosis of isolated nuclei is reported, indicating that AIF is a mitochondrial effector of apoptotic cell death.
Cerebral organoids model human brain development and microcephaly
A human pluripotent stem cell-derived three-dimensional organoid culture system that develops various discrete, although interdependent, brain regions that include a cerebral cortex containing progenitor populations that organize and produce mature cortical neuron subtypes is developed.
Angiotensin-converting enzyme 2 protects from severe acute lung failure
It is reported that ACE2 and the angiotensin II type 2 receptor (AT2) protect mice from severe acute lung injury induced by acid aspiration or sepsis, pointing to a possible therapy for a syndrome affecting millions of people worldwide every year.
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
OPGL is a new regulator of lymph-node organogenesis and lymphocyte development and is an essential osteoclast differentiation factor in vivo.
Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
An updated classification of cell death subroutines focusing on mechanistic and essential aspects of the process is proposed, and the utility of neologisms that refer to highly specialized instances of these processes are discussed.
Angiotensin-converting enzyme 2 is an essential regulator of heart function
These genetic data for ACE2 show that it is an essential regulator of heart function in vivo and targeted disruption of ACE2 in mice results in a severe cardiac contractility defect, increased angiotensin II levels, and upregulation of hypoxia-induced genes in the heart.
Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target
- Haibo Zhang, J. Penninger, Yimin Li, N. Zhong, Arthur S Slutsky
- Medicine, BiologyIntensive Care Medicine
- 3 March 2020
The rationale for angiotensin-converting enzyme 2 (ACE2) receptor as a specific target is reviewed, and a number of pharmaceuticals already being tested are tested but a better understanding of the underlying pathobiology is required.
Evidence for osteocyte regulation of bone homeostasis through RANKL expression
It is found that purified osteocytes express a much higher amount of receptor activator of nuclear factor-κB ligand (RANKL) and have a greater capacity to support osteoclastogenesis in vitro than osteoblasts and bone marrow stromal cells.