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RCAN1 gene

Known as: Regulator of Calcineurin 1 Gene, DOWN SYNDROME CRITICAL REGION GENE 1, CALCIPRESSIN 1 
This gene is involved in modulation of protein phosphorylation.
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Glioblastoma (GB) is the most common and aggressive primary brain malignancy, with poor prognosis and a lack of effective… Expand
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Highly Cited
2009
Highly Cited
2009
The calcium-activated protein phosphatase calcineurin is controlled by regulator of calcineurin (RCAN) in organisms ranging from… Expand
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Highly Cited
2006
Highly Cited
2006
Trisomy 21 results in Down's syndrome, but little is known about how a 1.5-fold increase in gene dosage produces the pleiotropic… Expand
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Highly Cited
2006
Highly Cited
2006
Hyperphosphorylated tau proteins accumulate in the paired helical filaments of neurofibrillary tangles seen in such tauopathies… Expand
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Highly Cited
2003
Highly Cited
2003
The calcium/calmodulin-dependent protein phosphatase calcineurin stimulates cardiac hypertrophy in response to numerous stimuli… Expand
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Highly Cited
2001
Highly Cited
2001
The DSCR1(Adapt78) gene was independently discovered as a resident of the “Down syndrome candidate region”and as an “adaptive… Expand
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Highly Cited
2000
Highly Cited
2000
Here we describe a small family of proteins, termed MCIP1 and MCIP2 (for myocyte-enrichedcalcineurin interacting protein), that… Expand
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Highly Cited
2000
Highly Cited
2000
Down syndrome is one of the major causes of mental retardation and congenital heart malformations. Other common clinical features… Expand
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Highly Cited
2000
Highly Cited
2000
The protein phosphatase calcineurin mediates many cellular responses to calcium signals. Using a genetic screen in yeast, we… Expand
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Highly Cited
1995
Highly Cited
1995
Down syndrome is a major cause of mental retardation and congenital heart defects. While most of the affected individuals have… Expand
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