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Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death
Cyclophilin D and the mitochondrial permeability transition are required for mediating Ca2+- and oxidative damage-induced cell death, but not Bcl-2 family member-regulated death. Expand
A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy
It is shown that cardiac hypertrophy is induced by the calcium-dependent phosphatase calcineurin, which dephosphorylates the transcription factor NF-AT3, enabling it to translocate to the nucleus. Expand
Regulation of cardiac hypertrophy by intracellular signalling pathways
Recent findings in genetically modified animal models implicate important intermediate signal-transduction pathways in the coordination of heart growth following physiological and pathological stimulation. Expand
Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis.
It is proposed that GATA4 is required for the migration or folding morphogenesis of the precardiogenic splanchnic mesodermal cells at the level of the AIP. Expand
Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death
The results indicate that Vdacs are dispensable for both MPT and Bcl-2 family member-driven cell death, as shown in mice with Vdac-deficient mitochondria. Expand
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
An updated classification of cell death subroutines focusing on mechanistic and essential aspects of the process is proposed, and the utility of neologisms that refer to highly specialized instances of these processes are discussed. Expand
Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins
Members of the myocyte enhancer factor-2 (MEF2) family of MADS domain transcription factors cannot induce myogenesis in transfected fibroblasts, but when coexpressed with the myogenicExpand
Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease
The CypD-mediated mitochondrial permeability transition pore is directly linked to the cellular and synaptic perturbations observed in the pathogenesis of Alzheimer's disease. Expand
The Zinc Finger-containing Transcription Factors GATA-4, -5, and -6
  • J. Molkentin
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 15 December 2000
Consistent with the observed expression patterns for GATA-4, -5, and -6, targeted disruption of each gene in the mouse has revealed important functions in heart, endoderm, lung epithelium, and genitourinary tract formation. Expand