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Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death
Mitochondria play a critical role in mediating both apoptotic and necrotic cell death. The mitochondrial permeability transition (mPT) leads to mitochondrial swelling, outer membrane rupture and theExpand
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A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy
In response to numerous pathologic stimuli, the myocardium undergoes a hypertrophic response characterized by increased myocardial cell size and activation of fetal cardiac genes. We show thatExpand
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Regulation of cardiac hypertrophy by intracellular signalling pathways
The mammalian heart is a dynamic organ that can grow and change to accommodate alterations in its workload. During development and in response to physiological stimuli or pathological insults, theExpand
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Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis.
The zinc finger transcription factor GATA4 has been implicated in heart development based on its early expression in precardiogenic splanchnic mesoderm and its ability to activate the expression of aExpand
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Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functionalExpand
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Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins
Members of the myocyte enhancer factor-2 (MEF2) family of MADS domain transcription factors cannot induce myogenesis in transfected fibroblasts, but when coexpressed with the myogenicExpand
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Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death
Mitochondria are critically involved in necrotic cell death induced by Ca2+ overload, hypoxia and oxidative damage. The mitochondrial permeability transition (MPT) pore — a protein complex that spansExpand
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Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease
Cyclophilin D (CypD, encoded by Ppif) is an integral part of the mitochondrial permeability transition pore, whose opening leads to cell death. Here we show that interaction of CypD withExpand
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Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury
An emerging concept is that the mammalian myocardium has the potential to regenerate, but that regeneration might be too inefficient to repair the extensive myocardial injury that is typical of humanExpand
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