Calcipressin-1

Known as: Myocyte-Enriched Calcineurin-Interacting Protein 1, Down Syndrome Critical Region Protein 1, Adapt78 
Calcipressin-1 (252 aa, ~28 kDa) is encoded by the human RCAN1 gene. This protein is involved in the regulation of transcription through the… (More)
National Institutes of Health

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Down SyndromeGenes, RegulatorRCAN1 geneRCAN1 wt Allele
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Papers overview

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2009
2009
Activation of adenylate cyclase by forskolin increases the protein stability of RCAN1 (DSCR1 or Adapt78).
Overexpression of Regulator of Calcineurin 1 (RCAN1/DSCR1/Adapt78) is known to inhibit the calcineurin-NFAT dependent signaling… (More)
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2008
2008
Exercise and regulation of mitochondrial biogenesis factors in human skeletal muscle
 
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2006
2006
ACE inhibition prevents myocardial infarction-induced skeletal muscle mitochondrial dysfunction.
Heart failure is associated with alterations in cardiac and skeletal muscle energy metabolism resulting in a generalized myopathy… (More)
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Highly Cited
2005
Highly Cited
2005
Estrogen inhibits cardiomyocyte hypertrophy in vitro. Antagonism of calcineurin-related hypertrophy through induction of MCIP1.
Evidence from in vivo studies suggests that some inputs to cardiac hypertrophy are opposed by the actions of estrogen. However… (More)
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Highly Cited
2004
Highly Cited
2004
Down syndrome critical region protein 1 (DSCR1), a novel VEGF target gene that regulates expression of inflammatory markers on activated endothelial cells.
We conducted a genome-wide analysis of genes that are regulated by vascular endothelial growth factor (VEGF) in endothelial cells… (More)
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2004
2004
Multiple oxidative stress-response members of the Adapt78 family.
Adapt78 is an oxidative and calcium stress-response gene. Its protein product is a potent natural inhibitor of the intracellular… (More)
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2003
2003
Oxidative and calcium stress regulate DSCR1 (Adapt78/MCIP1) protein.
DSCR1 (adapt78) is a stress-inducible gene and cytoprotectant. Its protein product, DSCR1 (Adapt78), also referred to as MCIP1… (More)
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Highly Cited
2000
Highly Cited
2000
Independent signals control expression of the calcineurin inhibitory proteins MCIP1 and MCIP2 in striated muscles.
Calcineurin, a calcium/calmodulin-regulated protein phosphatase, modulates gene expression in cardiac and skeletal muscles during… (More)
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2000
2000
adapt78 protects cells against stress damage and suppresses cell growth.
We have previously identified several genes whose RNA products are induced in HA-1 hamster cells under conditions where a… (More)
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1997
1997
Hamster adapt78 mRNA is a Down syndrome critical region homologue that is inducible by oxidative stress.
We are using the technique of mRNA differential display to identify RNAs that may be important in protecting cells against the… (More)
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