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Down Syndrome

Known as: Downs Syndrome, Down's syndrome, Trisomy 21 Syndrome 
A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Virtually all adults with Down syndrome (DS) show the neuropathological changes of Alzheimer disease (AD) by the age of 40 years… Expand
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Review
2019
Review
2019
The accumulation of pathological misfolded tau is a feature common to a collective of neurodegenerative disorders known as… Expand
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Review
2019
Review
2019
The human cerebellum has a protracted developmental timeline compared with the neocortex, expanding the window of vulnerability… Expand
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Review
2018
Review
2018
Mitochondria play a pivotal role in cellular energy-generating processes and are considered master regulators of cell life and… Expand
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Highly Cited
2010
Highly Cited
2010
Dyrk1A (dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A) is a serine/threonine kinase essential for brain… Expand
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Highly Cited
2004
Highly Cited
2004
The psychological well-being of mothers raising a child with a developmental disability varies with the nature of the disability… Expand
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Highly Cited
1999
Highly Cited
1999
The aims of this longitudinal study were: (1) to assess the continuity and change in diagnosis, intelligence, and language skills… Expand
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Highly Cited
1989
Highly Cited
1989
Interleukin 1, an immune response-generated cytokine that stimulates astrocyte proliferation and reactivity (astrogliosis), was… Expand
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Highly Cited
1985
Highly Cited
1985
We have purified and characterized the cerebral amyloid protein that forms the plaque core in Alzheimer disease and in aged… Expand
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Highly Cited
1985
Highly Cited
1985
One hundred brains of patients with Down's syndrome(DS) who died in insstitutions for chronic care were exemined for… Expand
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