Down Syndrome

Known as: Downs Syndrome, Down's syndrome, Trisomy 21 Syndrome 
A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include… (More)
National Institutes of Health

Papers overview

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Review
2017
Review
2017
OBJECTIVES To review clinical validation or implementation studies of maternal blood cell-free (cf) DNA analysis and define the… (More)
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Highly Cited
2007
Highly Cited
2007
Ts65Dn mice, a model for Down syndrome, have excessive inhibition in the dentate gyrus, a condition that could compromise… (More)
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Review
2004
Review
2004
The sequence of chromosome 21 was a turning point for the understanding of Down syndrome. Comparative genomics is beginning to… (More)
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Highly Cited
2002
Highly Cited
2002
Children with Down syndrome have a 10–20-fold elevated risk of developing leukemia, particularly acute megakaryoblastic leukemia… (More)
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Highly Cited
1995
Highly Cited
1995
Trisomy 21 or Down syndrome (DS) is the most frequent genetic cause of mental retardation, affecting one in 800 live born human… (More)
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Highly Cited
1995
Highly Cited
1995
DOWN'S syndrome (DS) or trisomy 21 is the most common genetic cause of mental retardation1. Development of the DS brain is… (More)
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Highly Cited
1994
Highly Cited
1994
Down syndrome (DS) is a major cause of mental retardation and congenital heart disease. Besides a characteristic set of facial… (More)
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Highly Cited
1989
Highly Cited
1989
Interleukin 1, an immune response-generated cytokine that stimulates astrocyte proliferation and reactivity (astrogliosis), was… (More)
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Highly Cited
1985
Highly Cited
1985
We have purified and characterized the cerebral amyloid protein that forms the plaque core in Alzheimer disease and in aged… (More)
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Highly Cited
1985
Highly Cited
1985
One hundred brains of patients with Down's syndrome (DS) who died in institutions for chronic care were examined for… (More)
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