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Acute Megakaryocytic Leukemias

Known as: LEUKEMIA, MEGAKARYOCYTIC, MALIGNANT, Thrombocytic leukemia, Acute Megakaryoblastic Leukemia 
An acute myeloid leukemia in which 20-30% of the bone marrow or peripheral blood cells are of megakaryocyte lineage. MYELOFIBROSIS or increased bone… Expand
National Institutes of Health

Related topics

Related topics

25 relations
Bone MarrowBone marrow stem cellCDISC SEND Tumor Findings Results TerminologyClinical Data Interchange Standards Consortium Terminology
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis.
Matrix stiffening and myofibroblast resistance to apoptosis are cardinal features of chronic fibrotic diseases involving diverse… Expand
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Highly Cited
2006
Highly Cited
2006
Activating alleles of JAK3 in acute megakaryoblastic leukemia.
Tyrosine kinases are aberrantly activated in numerous malignancies, including acute myeloid leukemia (AML). To identify tyrosine… Expand
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Highly Cited
2005
Highly Cited
2005
JAK2 mutation 1849G>T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome-negative CML, and megakaryocytic leukemia.
An activating 1849G>T mutation of JAK2 (Janus kinase 2) tyrosine kinase was recently described in chronic myeloproliferative… Expand
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Highly Cited
2003
Highly Cited
2003
GATA1 mutations in transient leukemia and acute megakaryoblastic leukemia of Down syndrome.
Children with constitutional trisomy 21 (Down syndrome) have an approximately 500-fold increased risk of developing acute… Expand
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Highly Cited
2003
Highly Cited
2003
Mutations in exon 2 of GATA1 are early events in megakaryocytic malignancies associated with trisomy 21.
Patients with Down syndrome (DS) frequently develop 2 kinds of clonal megakaryocytosis: a common, congenital, spontaneously… Expand
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Highly Cited
2002
Highly Cited
2002
Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome
Children with Down syndrome have a 10–20-fold elevated risk of developing leukemia, particularly acute megakaryoblastic leukemia… Expand
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Highly Cited
2001
Highly Cited
2001
Antibodies inhibit prion propagation and clear cell cultures of prion infectivity
Prions are the transmissible pathogenic agents responsible for diseases such as scrapie and bovine spongiform encephalopathy. In… Expand
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Highly Cited
1997
Highly Cited
1997
Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of…
In this study, we examined a large number of patients to clarify the distribution and frequency of a recently described FLT3… Expand
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Highly Cited
1994
Highly Cited
1994
Use of a monoclonal antibody directed against the platelet glycoprotein IIb/IIIa receptor in high-risk coronary angioplasty.
  • The New England journal of medicine
  • 1994
    • Corpus ID: 31685111
BACKGROUND Platelets are believed to play a part in the ischemic complications of coronary angioplasty, such as abrupt closure of… Expand
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Highly Cited
1992
Highly Cited
1992
Small B cells as antigen-presenting cells in the induction of tolerance to soluble protein antigens
We have investigated the ability of resting B cells, acting as antigen- presenting cells, to induce tolerance to soluble protein… Expand
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