FAQ

Acute Megakaryocytic Leukemias

Known as: LEUKEMIA, MEGAKARYOCYTIC, MALIGNANT, Thrombocytic leukemia, Acute Megakaryoblastic Leukemia 
An acute myeloid leukemia in which 20-30% of the bone marrow or peripheral blood cells are of megakaryocyte lineage. MYELOFIBROSIS or increased bone… (More)

Topic mentions per year

Topic mentions per year

1946-2017
0204019462016

Related topics

Related topics

23 relations
Bone MarrowBone marrow stem cellCDISC SEND Tumor Findings Results TerminologyClinical Data Interchange Standards Consortium Terminology
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Acute Megakaryocytic Leukemias
cancer cell
Leukemia, Myelocytic, Acute
Bone Marrow
Thrombocytopenia
radiotherapeutic

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
ERG is a megakaryocytic oncogene.
Ets-related gene (ERG) is a member of the ETS transcription factor gene family located on Hsa21. ERG is known to have a crucial… (More)
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Highly Cited
2006
Highly Cited
2006
Activating alleles of JAK3 in acute megakaryoblastic leukemia.
Tyrosine kinases are aberrantly activated in numerous malignancies, including acute myeloid leukemia (AML). To identify tyrosine… (More)
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Highly Cited
2006
Highly Cited
2006
Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling.
Individuals with Down syndrome (DS) are predisposed to develop acute megakaryoblastic leukemia (AMKL), characterized by… (More)
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Highly Cited
2005
Highly Cited
2005
JAK2 mutation 1849G>T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome-negative CML, and megakaryocytic leukemia.
An activating 1849G>T mutation of JAK2 (Janus kinase 2) tyrosine kinase was recently described in chronic myeloproliferative… (More)
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Highly Cited
2004
Highly Cited
2004
Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias
The phosphatidylinositol 3-kinase (PI3K)/AKT protein kinase pathway is involved in cell growth, proliferation, and apoptosis. The… (More)
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Highly Cited
2003
Highly Cited
2003
GATA1 mutations in transient leukemia and acute megakaryoblastic leukemia of Down syndrome.
Children with constitutional trisomy 21 (Down syndrome) have an approximately 500-fold increased risk of developing acute… (More)
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Highly Cited
2002
Highly Cited
2002
Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome
Children with Down syndrome have a 10–20-fold elevated risk of developing leukemia, particularly acute megakaryoblastic leukemia… (More)
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Highly Cited
2001
Highly Cited
2001
Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia
t(1;22) is the principal translocation of acute megakaryoblastic leukemias. Here we show this chromosomal rearrangement to result… (More)
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2000
2000
Acute megakaryocytic leukemia: the Eastern Cooperative Oncology Group experience.
Acute megakaryocytic leukemia (AMegL) is a rare subtype of acute myeloid leukemia (AML) evolving from primitive megakaryoblasts… (More)
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Highly Cited
1985
Highly Cited
1985
Establishment of a novel human megakaryoblastic leukemia cell line, MEG-01, with positive Philadelphia chromosome.
A megakaryoblastic cell line, designated MEG-01, was established from the bone marrow of a patient with blast crisis of… (More)
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