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Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3
The purification and cDNA cloning of Apaf-1, a novel 130 kd protein from HeLa cell cytosol that participates in the cytochrome c-dependent activation of caspase-3, leading to apoptosis is reported here. Expand
Slit Proteins Bind Robo Receptors and Have an Evolutionarily Conserved Role in Repulsive Axon Guidance
The characterization of three mammalian Slit homologs are described and it is shown that the Drosophila Slit protein and at least one of the mammals Slit proteins, Slit2, are proteolytically processed and show specific, high-affinity binding to Robo proteins. Expand
Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA
This work reports the identification, purification, and cDNA cloning of a novel MeCP called MeCP2, which unlike MeCP1, the new protein is able to bind to DNA that contains a single methyl-CpG pair. Expand
A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor
Mutational analysis identified a C-terminal region of 78 amino acids within the cytoplasmic domain of the human 75 kDa tumor necrosis factor receptor (TNF-R2) that is required for signalExpand
Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells.
A growth factor for vascular endothelial cells identified in the media conditioned by bovine pituitary follicular cells and purified to homogeneity by a combination of ammonium sulfate precipitation, heparin-sepharose affinity chromatography and two reversed phase HPLC steps is proposed to be named VGF on the basis of its apparent target cell selectivity. Expand
The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins
The biochemical purification and subsequent molecular cloning of two novel TNFR2-associated proteins, designated c-IAP1 and c- IAP2, that are closely related mammalian members of the inhibitor of apoptosis protein (IAP) family originally identified in baculoviruses are reported. Expand
IRAK: A Kinase Associated with the Interleukin-1 Receptor
A protein kinase designated IRAK (IL-1 receptor-associated kinase) was purified, and its complementary DNA was molecularly cloned and rapidly associated with the IL-1RI complex and was phosphorylated. Expand
MyD88: an adapter that recruits IRAK to the IL-1 receptor complex.
MyD88 plays the same role in IL-1 signaling as TRADD and Tube do in TNF and Toll pathways, respectively: it couples a serine/threonine protein kinase to the receptor complex. Expand
Biochemical Purification of a Mammalian Slit Protein as a Positive Regulator of Sensory Axon Elongation and Branching
Results indicate that Slit proteins may function as positive regulators of axon collateral formation during the establishment or remodeling of neural circuits. Expand
FIZZ1, a novel cysteine‐rich secreted protein associated with pulmonary inflammation, defines a new gene family
Bronchoalveolar lavage fluid from mice with experimentally induced allergic pulmonary inflammation contains a novel 9.4 kDa cysteine‐rich secreted protein, FIZZ1, which may modulate the function of neurons innervating the bronchial tree, thereby altering the local tissue response to allergic pulmonaryinflammatory. Expand