Amyloid beta-Protein Precursor

Known as: Nexin 2, Protease, Amyloid beta Precursor Protein, Amyloid beta Protein Precursor 
A single-pass type I membrane protein. It is cleaved by AMYLOID PRECURSOR PROTEIN SECRETASES to produce peptides of varying amino acid lengths. A 39… (More)

Topic mentions per year

Topic mentions per year

1980-2018
020040060019802018

Papers overview

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Review
2016
Review
2016
Over the past two decades, many studies have identified significant contributions of toxic β-amyloid peptides (Aβ) to the… (More)
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Highly Cited
2007
Highly Cited
2007
Many potential treatments for Alzheimer's disease target amyloid-beta peptides (Abeta), which are widely presumed to cause the… (More)
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Highly Cited
1999
Highly Cited
1999
Cerebral deposition of amyloid beta peptide (Abeta) is an early and critical feature of Alzheimer's disease. Abeta generation… (More)
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Highly Cited
1999
Highly Cited
1999
Amyloid-beta peptide (Abeta) seems to have a central role in the neuropathology of Alzheimer's disease (AD). Familial forms of… (More)
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Highly Cited
1999
Highly Cited
1999
Proteolytic processing of the amyloid precursor protein (APP) generates amyloid beta (Abeta) peptide, which is thought to be… (More)
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Highly Cited
1998
Highly Cited
1998
Point mutations in the presenilin-1 gene (PS1) are a major cause of familial Alzheimer's disease. They result in a selective… (More)
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Highly Cited
1997
Highly Cited
1997
Mutations in the amyloid precursor protein (APP) gene cause early-onset familial Alzheimer disease (AD) by affecting the… (More)
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Highly Cited
1995
Highly Cited
1995
Alzheimer's disease (AD) is the most common cause of progressive intellectual failure in aged humans. AD brains contain numerous… (More)
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Highly Cited
1992
Highly Cited
1992
Progressive cerebral deposition of the 39-43-amino-acid amyloid beta-protein (A beta) is an invariant feature of Alzheimer's… (More)
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Highly Cited
1991
Highly Cited
1991
A locus segregating with familial Alzheimer's disease (AD) has been mapped to chromosome 21, close to the amyloid precursor… (More)
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