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Amyloid beta-Protein Precursor

Known as: Nexin 2, Protease, Amyloid beta Precursor Protein, Amyloid beta Protein Precursor 
A single-pass type I membrane protein. It is cleaved by AMYLOID PRECURSOR PROTEIN SECRETASES to produce peptides of varying amino acid lengths. A 39… 
National Institutes of Health

Related topics

Related topics

29 relations

Narrower (13)

APLP1 protein, humanAPLP2 protein, humanAPP protein, humanAPP5-mer peptide
APP geneAlzheimer's DiseaseCTSB geneCTSB wt Allele

Broader (2)

AmyloidProtein Precursors

Papers overview

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2016
2016
[OP.2D.03] PULSATILE STRETCH ALTERS EXPRESSION AND PROCESSING OF AMYLOID PRECURSOR PROTEIN IN HUMAN CEREBRAL ENDOTHELIAL CELLS
Objective: Amyloid &bgr; (A&bgr;) deposition is a hallmark of Alzheimer's disease (AD). A&bgr; is generated via enzymatic… 
2014
2014
Traumatic brain injury: PET imaging detects amyloid deposits after TBI
A study by David Menon and colleagues has demonstrated that 11C-labelled Pittsburgh compound B (PiB)–PET imaging could enable… 
2005
2005
in press-uncorrected proof Rab 6 interacts with the mint 3 adaptor protein
The Rab6 GTPase regulates a retrograde transport route connecting endosomes and the endoplasmic reticulum (ER) via the Golgi… 
2005
2005
Alzheimer's Disease: Reducing the burden with ApoE2
A new approach to gene therapy for Alzheimer’s disease (AD), recently published in PNAS, shows efficacy in prevention and… 
2004
2004
Effects of presenilins and beta-amyloid precursor protein on delayed rectifier potassium channels in cultured rat hippocampal neurons.
AIM To study the effects of presenilin-1 (PS-1), presenilin-2 (PS-2), and amyloid beta-protein precursor (APP695) on delayed… 
2003
2003
A Novel Mutation in the PSEN 2 Gene ( T 430 M ) Associated With Variable Expression in a Family With Early-Onset Alzheimer Disease
Patients and Methods: The proband was a 49-yearold individual who displayed progressive dementia beginning at age 45 years. One… 
2002
2002
Gamma-secretase activity is not involved in presenilin-mediated regulation of beta-catenin.
Presenilins (PS) are involved in gamma-secretase-mediated processing of beta-amyloid precursor protein (APP) and the Notch family… 
1993
1993
Degeneration of amyloid precursor protein containing smooth muscle cells in cerebral amyloid angiopathy
1992
1992
Protein Kinases and Growth Associated Proteins in Plaque Formation in Alzheimer's Disease
1989
1989
Soluble derivatives of the beta amyloid protein precursor of Alzheimer's disease are labeled by antisera to the beta amyloid protein.
The amyloid deposited in Alzheimer's disease (AD) is composed primarily of a 39-42 residue polypeptide (beta AP) that is derived…