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Amyloid beta-Protein Precursor

Known as: Nexin 2, Protease, Amyloid beta Precursor Protein, Amyloid beta Protein Precursor 
A single-pass type I membrane protein. It is cleaved by AMYLOID PRECURSOR PROTEIN SECRETASES to produce peptides of varying amino acid lengths. A 39… Expand
National Institutes of Health

Papers overview

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Review
2018
Review
2018
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the main cause of dementia among the elderly worldwide… Expand
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Review
2017
Review
2017
Amyloid beta peptide (Aβ) is produced through the proteolytic processing of a transmembrane protein, amyloid precursor protein… Expand
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Review
2017
Review
2017
Amyloid precursor protein (APP) gives rise to the amyloid-β peptide and thus has a key role in the pathogenesis of Alzheimer… Expand
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Review
2011
Review
2011
Alzheimer's disease (AD), the leading cause of dementia worldwide, is characterized by the accumulation of the β-amyloid peptide… Expand
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Highly Cited
2007
Highly Cited
2007
Many potential treatments for Alzheimer's disease target amyloid-beta peptides (Abeta), which are widely presumed to cause the… Expand
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Highly Cited
2006
Highly Cited
2006
Mutations in the genes for amyloid precursor protein (APP) and presenilins (PS1, PS2) increase production of beta-amyloid 42… Expand
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Highly Cited
2000
Highly Cited
2000
Amyloid plaques are a neuropathological hallmark of Alzheimer's disease (AD), but their relationship to neurodegeneration and… Expand
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Highly Cited
1999
Highly Cited
1999
Cerebral deposition of amyloid beta peptide (Abeta) is an early and critical feature of Alzheimer's disease. Abeta generation… Expand
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Highly Cited
1997
Highly Cited
1997
Mutations in the amyloid precursor protein (APP) gene cause early-onset familial Alzheimer disease (AD) by affecting the… Expand
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Highly Cited
1991
Highly Cited
1991
A LOCUS segregating with familial Alzheimer's disease (AD) has been mapped to chromosome 21 (ref. 1), close to the amyloid… Expand
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