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Guidelines for the use and interpretation of assays for monitoring autophagy
These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Autophagy regulates lipid metabolism
A previously unknown function for autophagy in regulating intracellular lipid stores (macrolipophagy) is identified that could have important implications for human diseases with lipid over-accumulation such as those that comprise the metabolic syndrome.
Autophagy fights disease through cellular self-digestion
Understanding autophagy may ultimately allow scientists and clinicians to harness this process for the purpose of improving human health, and to play a role in cell death.
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
A set of guidelines for the selection and interpretation of the methods that can be used by investigators who are attempting to examine macroautophagy and related processes, as well as by reviewers who need to provide realistic and reasonable critiques of papers that investigate these processes are presented.
Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy.
It is found that wild-type alpha-synuclein was selectively translocated into lysosomes for degradation by the chaperone-mediated autophagy pathway, which may underlie the toxic gain-of-function by the pathogenic A53T and A30P mutants.
Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy
It is found that wild-type α-synuclein was selectively translocated into lysosomes for degradation by the chaperone-mediated autophagy pathway, which may underlie the toxic gain-of-function by the A53T and A30P mutants.
Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations
A Receptor for the Selective Uptake and Degradation of Proteins by Lysosomes
Overexpression of human LGP96 in Chinese hamster ovary cells increased the activity of the selective lysosomal proteolytic pathway in vivo and in vitro.
Extensive Involvement of Autophagy in Alzheimer Disease: An Immuno-Electron Microscopy Study
This work unequivocally identified autophagosomes and other prelysosomal autophagic vacuoles (AVs), which were morphologically and biochemically similar to AVs highly purified from mouse liver, and provides the first evidence that macroautophagy is extensively involved in the neurodegenerative/regenerative process in AD.
Chaperone-mediated autophagy: roles in disease and aging
Recent advances in the understanding of the molecular dynamics, regulation and physiology of chaperone-mediated autophagy are described, and the evidence in support of the contribution of CMA dysfunction to severe human disorders such as neurodegeneration and cancer is discussed.