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Heart Valve Development: Regulatory Networks in Development and Disease
TLDR
The cellular and molecular mechanisms underlying the early development of valve progenitors and establishment of normal valve structure and function are reviewed. Expand
Cardiac Fibrosis: The Fibroblast Awakens.
TLDR
Current knowledge regarding the origins and roles of fibroblasts, mediators and signaling pathways known to influence fibroblast function after myocardial injury are summarized, as well as novel therapeutic strategies under investigation to attenuate cardiac fibrosis are summarized. Expand
Heart valve structure and function in development and disease.
TLDR
The mature heart valves are made up of highly organized extracellular matrix (ECM) and valve interstitial cells (VICs) surrounded by an endothelial cell layer that confer distinct biomechanical properties to the leaflets and supporting structures. Expand
Expression of the atrial-specific myosin heavy chain AMHC1 and the establishment of anteroposterior polarity in the developing chicken heart.
TLDR
Data indicate that retinoic acid treatment produces an expansion of the posterior (atrial) domain of the heart and suggests that diversified fates of cardiomyogenic progenitors can be altered. Expand
FoxO Transcription Factors Promote Autophagy in Cardiomyocytes*
TLDR
Evidence is provided for an important role for FoxO1 and FoxO3 in regulating autophagy and cell size in cardiomyocytes and in vivo studies show that cellular stress, such as starvation or ischemia/reperfusion in mice, results in induction ofAutophagy in the heart with concomitant dephosphorylation of FoxO, consistent with increased activity of nuclear FoxO transcription factors. Expand
Extracellular Matrix Remodeling and Organization in Developing and Diseased Aortic Valves
TLDR
These studies show that normal valve development is characterized by spatiotemporal coordination of ECM organization and VIC compartmentalization and that these developmental processes are disrupted in pediatric patients with diseased BAVs. Expand
FoxO Transcription Factors Promote Cardiomyocyte Survival upon Induction of Oxidative Stress*
TLDR
A critical role for FoxOs is supported in promoting cardiomyocyte survival during conditions of oxidative stress through induction of antioxidants and cell survival pathways. Expand
Development of heart valve leaflets and supporting apparatus in chicken and mouse embryos
TLDR
Analysis of Tie2‐cre × ROSA26R mice and chicken embryos provides novel insights into the origins and cell lineage diversity of mature valve structures in the developing vertebrate heart. Expand
Ventricular expression of tbx5 inhibits normal heart chamber development.
TLDR
Direct evidence is provided for an essential role for tbx5 in early heart morphogenesis and chamber-specific gene expression in vertebrate embryos and in humans with Holt-Oram syndrome. Expand
Hearts and bones: shared regulatory mechanisms in heart valve, cartilage, tendon, and bone development.
TLDR
This review will focus on the regulatory hierarchies that control normal and abnormal heart valve development in parallel with other connective tissue cell types. Expand
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