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APP processing is regulated by cytoplasmic phosphorylation
Results suggest that T668 phosphorylation may facilitate the BACE1 cleavage of APP to increase Aβ generation. Expand
Identification of the Mechanisms Regulating the Differential Activation of the MAPK Cascade by Epidermal Growth Factor and Nerve Growth Factor in PC12 Cells*
Together, these data provide a signaling link between growth factor receptors and MAPK activation and a mechanistic explanation of the differential MAPK kinetics exhibited by these growth factors. Expand
Calcineurin/NFAT Signaling Is Required for Neuregulin-Regulated Schwann Cell Differentiation
It is demonstrated that calcineurin and NFAT are essential for neuregulin and ErbB signaling, neural crest diversification, and differentiation of Schwann cells. Expand
β-Amyloid Stimulation of Microglia and Monocytes Results in TNFα-Dependent Expression of Inducible Nitric Oxide Synthase and Neuronal Apoptosis
A functional linkage between β-amyloid-dependent activation of microglia and several characteristic markers of neuronal death occurring in Alzheimer's disease brains is demonstrated. Expand
Pbx/Meis Deficiencies Demonstrate Multigenetic Origins of Congenital Heart Disease
Congenital heart diseases are traditionally considered to be multifactorial in pathogenesis resulting from environmental and genetic interactions that determine penetrance and expressivity within aExpand
Pbx1 functions in distinct regulatory networks to pattern the great arteries and cardiac outflow tract
It is demonstrated that the homeodomain transcription factor Pbx1 orchestrates separate transcriptional pathways to control great-artery patterning and cardiac OFT septation in mice and makes a crucial contribution to distinct regulatory pathways in cardiovascular development. Expand
beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis.
A functional linkage between beta-amyloid-dependent activation of microglia and several characteristic markers of neuronal death occurring in Alzheimer's disease brains is demonstrated. Expand
BACE1 Suppression by RNA Interference in Primary Cortical Neurons*
The results indicate that BACE1 siRNA specifically impacts on β-cleavage of APP and may be a potential therapeutic approach for treating AD. Expand
Safe, Long-term Hepatic Expression of Anti-HCV shRNA in a Nonhuman Primate Model
  • D. Suhy, S. Kao, +18 authors R. Corbau
  • Biology, Medicine
  • Molecular therapy : the journal of the American…
  • 26 June 2012
A novel drug is described, intended as a “single-shot ” therapy, which expresses three short hairpin RNAs (shRNAs) that simultaneously target multiple conserved regions of the HCV genome as confirmed in vitro by knockdown of an HCV replicon system. Expand
Down Syndrome Critical Region-1 Is a Transcriptional Target of Nuclear Factor of Activated T Cells-c1 within the Endocardium during Heart Development*
The studies indicate that the DSCR1 gene is a direct transcriptional target of NFATc1 proteins within the endocardium during a critical window of heart valve formation. Expand