Skip to search formSkip to main contentSkip to account menu

Primaquine

Known as: 8-((4-Amino-1-methylbutyl)amino)-6-methoxyquinoline, Primaquin, Primachin 
A synthetic, 8-aminoquinoline derivative with antimalarial properties. Although its mechanism of action is unclear, primaquine bind to and alter the… 
National Institutes of Health

Related topics

Related topics

26 relations

Narrower (11)

2-tert-butylprimaquine5-hydroxyprimaquine6-demethylprimaquineM 8506

Broader (2)

AntimalarialsQuinolines
Decreased Protein Synthesis [PE]Drug AllergyIn BloodMalaria

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2000
2000
Factores asociados con el incumplimiento del tratamiento antipalúdico en pacientes ecuatorianos
Un total de 249 personas residentes del noroccidente del Ecuador, con diagnóstico clínico de paludismo, confirmado mediante tis… 
Highly Cited
1999
Highly Cited
1999
QUIMIOTERAPIA DE LA ENFERMEDAD DE CHAGAS
1997
1997
Primaquine alters antioxidant enzyme profiles in rat liver and kidney.
The effects of primaquine treatment on antioxidant enzyme activities were investigated in rat liver and kidney. Male Sprague… 
1987
1987
Seven patients with relapses of Plasmodium vivax or P. ovale despite primaquine treatment.
Seven relapses of Plasmodium vivax or Plasmodium ovale despite standard treatment with primaquine (3.0 mg Kg-1) daily for… 
1984
1984
Excretion, distribution, and metabolism of primaquine in rats.
The metabolism of the 8-aminoquinoline antimalarial drug, primaquine (I) was studied using rats. The drug was administered… 
1984
1984
High-performance liquid chromatographic-ultraviolet determination of primaquine and its metabolites in human plasma and urine.
A high-performance liquid chromatographic method was developed for the simultaneous determination of primaquine and its… 
1977
1977
Modifications of primaquine as antimalarials. 1. 5-Phenoxy derivatives of primaquine.
Various 5-phenoxy derivatives of primaquine have been prepared which are more active and less toxic than the parent compound in… 
1967
1967
The haemolytic effect of various regimens of primaquine with chloroquine in American Negroes with G6PD deficiency and the lack of an effect of various antimalarial suppressive agents on erythrocyte…
In view of the fact that increased resistance to drugs by malaria parasites in some parts of the world may lead to increasing use… 
1958
1958
Biochemical and genetic aspects of primaquine-sensitive hemolytic anemia.
Excerpt Acute hemolysis, which may destroy half the red cells within a few days, occurs in approximately 10% of otherwise healthy… 
Highly Cited
1957
Highly Cited
1957
The mechanism of glutathione destruction and protection in drug-sensitive and non-sensitive erythrocytes; in vitro studies.
When the anti-malarial drug primaquine or certain related aniline derivatives, such as sulfanilamide and acetanilid, are… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)