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Primaquine

Known as: 8-((4-Amino-1-methylbutyl)amino)-6-methoxyquinoline, Primaquin, Primachin 
A synthetic, 8-aminoquinoline derivative with antimalarial properties. Although its mechanism of action is unclear, primaquine bind to and alter the… Expand
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Falciparum malaria is transmitted by anopheline mosquitoes that have fed on blood containing gametocytes of Plasmodium falciparum… Expand
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Highly Cited
2013
Highly Cited
2013
BackgroundThe efficacy of the 8-aminoquinoline (8AQ) drug primaquine (PQ) has been historically linked to CYP-mediated metabolism… Expand
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Highly Cited
2012
Highly Cited
2012
Rosalind Howes and colleagues present a map of glucose-6-phosphate dehydrogenase deficiency prevalence and severity. Individuals… Expand
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Highly Cited
2010
Highly Cited
2010
Summary Background Artemisinin-combination therapy (ACT) is recommended as first-line treatment of falciparum malaria throughout… Expand
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2010
2010
BackgroundPlasmodium vivax has a dormant hepatic stage, called the hypnozoite, which can cause relapse months after the initial… Expand
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Highly Cited
2009
Highly Cited
2009
Primaquine, an 8-aminoquinoline, is the drug of choice for radical cure of relapsing malaria. Use of primaquine is limited due to… Expand
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Highly Cited
2008
Highly Cited
2008
Primaquine (PQ) is one of the most widely used antimalarial and is the only available drug till date to combat relapsing form of… Expand
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Highly Cited
2007
Highly Cited
2007
Background P. falciparum gametocytes may persist after treatment with sulphadoxine-pyrimethamine (SP) plus artesunate (AS) and… Expand
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Highly Cited
2001
Highly Cited
2001
We tested tafenoquine (WR 238605), a new long-acting 8-aminoquinoline, for its ability to prevent malaria in an area that is… Expand
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Highly Cited
1956