Skip to search formSkip to main contentSkip to account menu

5-hydroxyprimaquine

Known as: 5-HPQ 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Primaquine
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Formation primaquine-5,6-orthoquinone, the putative active and toxic metabolite of primaquine via direct oxidation in human erythrocytes
BackgroundThe activity and haemolytic toxicity associated with primaquine has been linked to its reactive metabolites. The… 
2005
2005
Primaquine-Induced Hemolytic Anemia: Role of Membrane Lipid Peroxidation and Cytoskeletal Protein Alterations in the Hemotoxicity of 5-Hydroxyprimaquine
Primaquine-induced hemolytic anemia is a toxic side effect that is due to premature splenic sequestration of intact erythrocytes… 
2005
2005
Primaquine-Induced Hemolytic Anemia: Role of Splenic Macrophages in the Fate of 5-Hydroxyprimaquine-Treated Rat Erythrocytes
Primaquine-induced hemolytic anemia is known to result from premature sequestration of damaged (but intact) erythrocytes by the… 
Highly Cited
2004
Highly Cited
2004
Primaquine-Induced Hemolytic Anemia: Susceptibility of Normal versus Glutathione-Depleted Rat Erythrocytes to 5-Hydroxyprimaquine
Primaquine is an important antimalarial agent because of its activity against exoerythrocytic forms of Plasmodium spp… 
1996
1996
High-performance liquid chromatographic determination of primaquine and carboxyprimaquine concentrations in plasma and blood cells in Plasmodium vivax malaria cases following chronic dosage with…
1994
1994
Oxidative activity of primaquine metabolites on rat erythrocytes in vitro and in vivo.
Highly Cited
1992
Highly Cited
1992
Hydroxylated metabolites of the antimalarial drug primaquine. Oxidation and redox cycling.
1991
1991
Susceptibility of glucose-6-phosphate dehydrogenase deficient red cells to primaquine, primaquine enantiomers, and its two putative metabolites. II. Effect on red blood cell membrane, lipid…
1987
1987
Photooxidation products of primaquine Structure, antimalarial activity and hemolytic effects
1985
1985
Structure-activity relationships of putative primaquine metabolites causing methemoglobin formation in canine hemolysates.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)