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5-hydroxyprimaquine

Known as: 5-HPQ 
 
National Institutes of Health

Papers overview

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2014
2014
BackgroundPrimaquine, currently the only approved drug for the treatment and radical cure of Plasmodium vivax malaria, is still… Expand
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2011
2011
We suggest a possible mechanism of how 8-aminoquinolines (8-AQ's) cause hemotoxicity by oxidizing hemoglobin to methemoglobin. In… Expand
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2005
2005
Primaquine-induced hemolytic anemia is a toxic side effect that is due to premature splenic sequestration of intact erythrocytes… Expand
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2005
2005
Primaquine-induced hemolytic anemia is known to result from premature sequestration of damaged (but intact) erythrocytes by the… Expand
Highly Cited
2004
Highly Cited
2004
Primaquine is an important antimalarial agent because of its activity against exoerythrocytic forms of Plasmodium spp… Expand
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1996
1996
A reversed-phase HPLC method using acetonitrile-methanol-1 M perchloric acid-water (30:9:1:95, v/v) at a flow-rate of 1.5 ml/min… Expand
1994
1994
The oxidative activities of primaquine [6-methoxy-8-(4-amino-1-methylbutylamino)quinoline] and its metabolites, the quinone-imine… Expand
Highly Cited
1992
Highly Cited
1992
Oxidation and redox cycling of the hydroxylated metabolites of the antimalarial drug primaquine (i.e. 5-hydroxyprimaquine, 5… Expand
1988
1988
The effects of the primaquine (PQ) enantiomers, (+)PQ and (-)PQ, and two putative metabolites [5-hydroxyprimaquine (5HPQ) and 6… Expand
1985
1985
A rapid and reproducible in vitro test system was developed to measure the methemoglobin (MHb)-forming properties of various 8… Expand