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5-hydroxyprimaquine

Known as: 5-HPQ 
National Institutes of Health

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2 relations

Broader (1)

Primaquine
analogs & derivatives

Papers overview

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2019
2019
Formation primaquine-5,6-orthoquinone, the putative active and toxic metabolite of primaquine via direct oxidation in human erythrocytes
The activity and haemolytic toxicity associated with primaquine has been linked to its reactive metabolites. The reactive… 
2013
2013
Methemoglobin generation by 8-aminoquinolines: effect of substitution at 5-position of primaquine.
Currently, the only clinically approved antimalarial drug to treat relapsing malaria is primaquine (PQ), yet PQ administration… 
2011
2011
Methemoglobinemia caused by 8-aminoquinoline drugs: DFT calculations suggest an analogy to H4B's role in nitric oxide synthase.
We suggest a possible mechanism of how 8-aminoquinolines (8-AQ's) cause hemotoxicity by oxidizing hemoglobin to methemoglobin. In… 
1991
1991
Susceptibility of glucose-6-phosphate dehydrogenase deficient red cells to primaquine, primaquine enantiomers, and its two putative metabolites. II. Effect on red blood cell membrane, lipid…
1990
1990
ESR detection of free radical intermediates during autoxidation of 5-hydroxyprimaquine.
Autoxidation of 5-hydroxyprimaquine, a putative metabolite of the antimalarial primaquine, was studied by oxygen consumption and… 
1987
1987
Photooxidation products of primaquine Structure, antimalarial activity and hemolytic effects
1986
1986
Characterization of the Urinary Metabolites of Primaquine in Rats
Following the synthesis of reference standards of the primaquine metabolites, a high-performance liquid chromatographic (HPLC… 
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