N. Nanayakkara

Publications32
h-index10
Citations384
Highly Influential Citations14
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Kavalactones from Piper methysticum, and their 13C NMR spectroscopic analyses.
The kavalactone, 11-methoxy-5,6-dihydroyangonin, and eight previously reported analogs along with four other aromatic compounds were isolated from the root extracts of Piper methysticum (Kava Kava).… Expand
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Improved high-performance liquid chromatographic separation of the Stevia rebaudiana sweet diterpene glycosides using linear gradient elution
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In vitro propagation of Podophyllum peltatum.
The lignan podophyllotoxin, occurring in Podophyllum emodi Wall, ex Royale and Podophyllum peltatum. L., is the starting compound for the semi-synthesis of the anticancer drugs etoposide and… Expand
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Schistosomicidal and trypanocidal structure-activity relationships for (±)-licarin A and its (-)- and (+)-enantiomers.
(±)-Licarin A (1) was obtained by oxidative coupling, and its enantiomers, (-)-licarin A (2) and (+)-licarin A (3), were resolved by chiral HPLC. Schistosomicidal and trypanocidal activities of these… Expand
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Effect of Aliphatic Side-Chain Substituents on the Antimalarial Activity and on the Metabolism of Primaquine Studied Using Mitochondria and Microsome Preparations
The substitution of two deuterium atoms on the α-carbon of the primaquine side chain was found to produce a sevenfold decrease in the rate of conversion of primaquine to carboxyprimaquine by… Expand
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A Utilization of the Selective Inept Experiment for the Structure Elucidation of Oxygenated Chromenes
Abstract A utilization of the selective INEPT experiment in which polarization transfer is effected through the chelated hydroxyl groups is described for the structure elucidation of two isomeric… Expand
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Quercetin Potentiates Toxicity Of Hemolytic Drugs In G6PD Deficient Human Erythrocytes
Quercetin, a flavonoid, is widely distributed in plants and a prominent constituent of dietary supplements. Quercetin-based supplements are recommended for prevention of cancer, improvement of… Expand
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Antiprotozoal and antimicrobial compounds from the plant pathogen Septoria pistaciarum.
Four new 1,4-dihydroxy-5-phenyl-2-pyridinone alkaloids, 17-hydroxy-N-(O-methyl)septoriamycin A (1), 17-acetoxy-N-(O-methyl)septoriamycin A (2), 13-(S)-hydroxy-N-(O-methyl)septoriamycin A (3), and… Expand
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Bioactive 1,4-dihydroxy-5-phenyl-2-pyridinone alkaloids from Septoria pistaciarum.
Four new 1,4-dihydroxy-5-phenyl-2-pyridinone alkaloids (1-4) were isolated from an EtOAc extract of a culture medium of Septoria pistaciarum. The structures of these compounds were determined by… Expand
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Methemoglobinemia caused by 8-aminoquinoline drugs: DFT calculations suggest an analogy to H4B's role in nitric oxide synthase.
We suggest a possible mechanism of how 8-aminoquinolines (8-AQ's) cause hemotoxicity by oxidizing hemoglobin to methemoglobin. In our DFT calculations, we found that 5-hydroxyprimaquine is able to… Expand
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