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Nitrogen dioxide and carbonate radical anion: two emerging radicals in biology.
Reactions of yeast thioredoxin peroxidases I and II with hydrogen peroxide and peroxynitrite: rate constants by competitive kinetics.
Even free radicals should follow some rules: a guide to free radical research terminology and methodology.
Nitrite as the major source of nitric oxide production by Arabidopsis thaliana in response to Pseudomonas syringae
Direct EPR Detection of the Carbonate Radical Anion Produced from Peroxynitrite and Carbon Dioxide*
- M. Bonini, R. Radi, G. Ferrer-Sueta, A. M. Ferreira, O. Augusto
- ChemistryThe Journal of Biological Chemistry
- 16 April 1999
This is the first report unambiguously demonstrating the formation of the carbonate radical anion at physiological pHs by direct EPR spectroscopy, contributing to the understanding of nitrosoperoxocarboxylate decomposition pathways.
Uric acid oxidation by peroxynitrite: multiple reactions, free radical formation, and amplification of lipid oxidation.
- C. X. Santos, E. I. Anjos, O. Augusto
- Chemistry, BiologyArchives of biochemistry and biophysics
- 15 December 1999
It is demonstrated that the aminocarbonyl radical is likely to be the species responsible for the effects of urate in amplifying peroxynitrite-mediated oxidation of liposomes and LDL, which was monitored by the formation of lipid peroxides and thiobarbituric acid-reactive substances.
Reduction of 1-Cys peroxiredoxins by ascorbate changes the thiol-specific antioxidant paradigm, revealing another function of vitamin C
- G. Monteiro, B. B. Horta, Daniel Carvalho Pimenta, O. Augusto, L. Netto
- BiologyProceedings of the National Academy of Sciences
- 20 March 2007
Ascorbate may be the long-sought-after biological reductant of 1-Cys Prx, and this data represents a breakthrough in the thiol-specific antioxidant paradigm.
Connecting the chemical and biological properties of nitric oxide.
It is emphasized that any claimed biological action of NO(•) should be connected with its interaction with kinetically relevant biotargets, and taking reactivity into account is important to advancing knowledge on redox signaling mechanisms.
The carbonate radical and related oxidants derived from bicarbonate buffer
The biochemical properties of both the carbonate radical and peroxymonocarbonate are reviewed, and the evidence of their formation under physiological conditions is discussed, emphasizing the recognition of the biological relevance of oxidants derived from the main physiological buffer.