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Complement activation by Cremophor EL as a possible contributor to hypersensitivity to paclitaxel: an in vitro study.
- J. Szebeni, F. Muggia, C. Alving
- Medicine, Biology
- Journal of the National Cancer Institute
- 18 February 1998
BACKGROUND Cancer patients treated with the anticancer drug, paclitaxel (Taxol) often experience mild to severe hypersensitivity reactions. It is not known how these reactions are induced and whether… Expand
Complement activation following first exposure to pegylated liposomal doxorubicin (Doxil): possible role in hypersensitivity reactions.
- A. Chanan-Khan, J. Szebeni, +4 authors F. Muggia
- Annals of oncology : official journal of the…
- 1 September 2003
BACKGROUND Pegylated liposomal doxorubicin (Doxil) has been reported to cause immediate hypersensitivity reactions (HSRs) that cannot be explained as IgE-mediated (type I) allergy. Previous in vitro… Expand
The Role of Complement Activation in Hypersensitivity to Pegylated Liposomal Doxorubicin (Doxil®)
Abstract Liposomal formulations of some drugs, most importantly pegylated liposomal doxorubicin (Doxil®), have been reported to cause immediate hypersensitivity reactions that cannot be explained… Expand
Hemodynamic changes induced by liposomes and liposome-encapsulated hemoglobin in pigs: a model for pseudoallergic cardiopulmonary reactions to liposomes. Role of complement and inhibition by soluble…
BACKGROUND Intravenous administration of some liposomal drugs can trigger immediate hypersensitivity reactions that include symptoms of cardiopulmonary distress. The mechanism underlying the… Expand
Transcutaneous immunization: A human vaccine delivery strategy using a patch
- G. M. Glenn, D. Taylor, Xiuru Li, S. Frankel, A. Montemarano, C. Alving
- Nature Medicine
- 1 December 2000
Transcutaneous immunization, a topical vaccine application, combines the advantages of needle-free delivery while targeting the immunologically rich milieu of the skin. In animal studies, this simple… Expand
Skin immunization made possible by cholera toxin
Immunization using an application to the skin surface, without physical penetration by needles, would greatly increase the ease of vaccination. In orally and nasally administered vaccines, the… Expand
HIV-1 neutralizing antibodies in the genital and respiratory tracts of mice intranasally immunized with oligomeric gp160.
Because mucosal surfaces are a primary route of HIV-1 infection, we evaluated the mucosal immunogenicity of a candidate HIV-1 vaccine, oligomeric gp160 (o-gp160). In prior studies, parenteral… Expand
Adjuvants for human vaccines.
- C. Alving, Kristina K. Peachman, M. Rao, S. Reed
- Biology, Medicine
- Current opinion in immunology
- 1 June 2012
Rational selection of individual adjuvants can often be made on the basis of innate molecular interactions of the foreign molecules with pattern recognition receptors such as Toll-like receptors. For… Expand
Design and selection of vaccine adjuvants: animal models and human trials.
- C. Alving
- 31 May 2002
The availability of hundreds of different adjuvants has prompted a need for identifying rational standards for selection of adjuvant formulations based on safety and sound immunological principles… Expand
Liposome-induced pulmonary hypertension: properties and mechanism of a complement-mediated pseudoallergic reaction.
- J. Szebeni, L. Baranyi, +6 authors C. Alving
- American journal of physiology. Heart and…
- 1 September 2000
Intravenous injection of liposomes can cause significant pulmonary hypertension in pigs, a vasoconstrictive response that provides a sensitive model for the cardiopulmonary distress in humans caused… Expand