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Free radicals in biology and medicine
1. Oxygen is a toxic gas - an introductionto oxygen toxicity and reactive species 2. The chemistry of free radicals and related 'reactive species' 3. Antioxidant defences Endogenous and Diet DerivedExpand
The presence of glutathione and glutathione reductase in chloroplasts: A proposed role in ascorbic acid metabolism
It is proposed that glutathione functions to stabilise enzymes of the Calvin cycle, and it may also act to keep ascorbic acid in chloroplasts in the reduced form. Expand
Oxidative stress and neurodegeneration: where are we now?
  • B. Halliwell
  • Biology, Medicine
  • Journal of neurochemistry
  • 1 June 2006
After a long lag period, therapeutic and other interventions based on a knowledge of redox biology are on the horizon for at least some of the neurodegenerative diseases. Expand
Reactive Oxygen Species and the Central Nervous System
  • B. Halliwell
  • Chemistry, Medicine
  • Journal of neurochemistry
  • 1 November 1992
The nature of antioxidants is discussed, it being suggested that antioxidant enzymes and chelators of transition metal ions may be more generally useful protective agents than chain‐breaking antioxidants. Expand
Reactive Species and Antioxidants. Redox Biology Is a Fundamental Theme of Aerobic Life
The field of antioxidants and free radicals is often perceived as focusing around the use of antioxidant supplements to prevent human disease. In fact, antioxidants/free radicals permeate the wholeExpand
Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean?
Methods used to trap RS, including spin trapping and aromatic hydroxylation, are critically examined, with a particular emphasis on those methods applicable to human studies and methods used to detect RS in cell culture. Expand
Role of free radicals and catalytic metal ions in human disease: an overview.
The chapter discusses the metabolism of transition metals, such as iron and copper, and the chelation therapy that is an approach to site-specific antioxidant protection. Expand
The deoxyribose method: a simple "test-tube" assay for determination of rate constants for reactions of hydroxyl radicals.
It is suggested that the deoxyribose assay is a simple and cheap alternative to pulse radiolysis for determination of rate constants for reaction of most biological molecules with hydroxyl radicals. Expand
Lipid peroxidation: its mechanism, measurement, and significance.
An increased concentration of end products of lipid peroxidation is the evidence most frequently quoted for the involvement of free radicals in human disease. However, it is likely that increasedExpand