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PSMB8 gene

Known as: PSMB8, beta5i, Proteasome (Prosome, Macropain) Subunit, Beta Type, 8 Gene 
This gene plays a role in both protein catabolism and antigen processing.
National Institutes of Health

Related topics

Related topics

6 relations
Antigen ProcessingHydrolysisPSMB8 protein, humanProtein Degradation, Regulatory

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Radiographic severity of ankylosing spondylitis is associated with polymorphism of the large multifunctional peptidase 2 gene in the Spondyloarthritis Research Consortium of Canada cohort.
OBJECTIVE There are limited data on genetic predictors of radiographic progression. The aim of this study was to examine… 
2003
2003
The antigen processing machinery of class I human leukocyte antigens: linked patterns of gene expression in neoplastic cells.
The ultimate outcome of an immune response (escape or surveillance) depends on a delicate balance of opposing signals delivered… 
Highly Cited
2002
Highly Cited
2002
Proteasome, Transporter Associated with Antigen Processing, and Class I Genes in the Nurse Shark Ginglymostoma cirratum: Evidence for a Stable Class I Region and MHC Haplotype Lineages1
Cartilaginous fish (e.g., sharks) are derived from the oldest vertebrate ancestor having an adaptive immune system, and thus are… 
Highly Cited
1997
Highly Cited
1997
Linkage of LMP, TAP, and RING3 with Mhc class I rather than class II genes in the zebrafish.
The LMP2 and LMP7 genes code for subunits of the proteasome, a multimeric enzymatic complex that degrades proteins into peptides… 
1997
1997
No Independent Associations of LMP2 and LMP7 Polymorphisms With Susceptibility to Develop IDDM
Results from a recent study suggested that polymorphisms within the HLA class II genes LMP2 and LMP7 were associated with the… 
Highly Cited
1996
Highly Cited
1996
Isolation of low molecular mass polypeptide complementary DNA clones from primitive vertebrates. Implications for the origin of MHC class I-restricted antigen presentation.
Proteasomes are the multisubunit proteases thought to be involved in the generation of peptides presented by MHC class I… 
Highly Cited
1995
Highly Cited
1995
Association of LMP2 and LMP7 genes within the major histocompatibility complex with insulin-dependent diabetes mellitus: population and family studies.
LMP2 and LMP7, two subunits of the proteasomes encoded in the major histocompatibility complex, are speculated to play a role in… 
Highly Cited
1994
Highly Cited
1994
Proteasome components with reciprocal expression to that of the MHC-encoded LMP proteins
Highly Cited
1994
Highly Cited
1994
MHC-encoded proteasome subunits LMP2 and LMP7 are not required for efficient antigen presentation.
LMP2 and LMP7 are proteins encoded by MHC genes that are tightly linked to the genes encoding TAP, the transporter that conveys… 
Highly Cited
1992
Highly Cited
1992
Alternative exon usage and processing of the major histocompatibility complex-encoded proteasome subunits.
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