Skip to search formSkip to main contentSkip to account menu

PSMB8 gene

Known as: PSMB8, beta5i, Proteasome (Prosome, Macropain) Subunit, Beta Type, 8 Gene 
This gene plays a role in both protein catabolism and antigen processing.
National Institutes of Health

Related topics

Related topics

6 relations
Antigen ProcessingHydrolysisPSMB8 protein, humanProtein Degradation, Regulatory

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Histone deacetylase inhibitors induce TAP, LMP, Tapasin genes and MHC class I antigen presentation by melanoma cells
Histone deacetylase inhibitors (HDACi), including trichostatin A (TSA) and valproic acid, can alter the acetylation of histones… 
Highly Cited
1995
Highly Cited
1995
Incorporation of major histocompatibility complex – encoded subunits LMP2 and LMP7 changes the quality of the 20S proteasome polypeptide processing products independent of interferon‐γ
The 20S proteasome is the enzyme complex responsible for the processing of antigens bound by major histocompatibility complex… 
Highly Cited
1995
Highly Cited
1995
The Interferon-γ-inducible 11 S Regulator (PA28) and the LMP2/LMP7 Subunits Govern the Peptide Production by the 20 S Proteasome in Vitro(*)
Antigenic peptides presented on major histocompatibility complex (MHC) class I molecules to cytotoxic T cells are generated in… 
Highly Cited
1994
Highly Cited
1994
Altered peptidase and viral-specific T cell response in LMP2 mutant mice.
Highly Cited
1994
Highly Cited
1994
Peptidase activities of proteasomes are differentially regulated by the major histocompatibility complex-encoded genes for LMP2 and LMP7.
Recent studies have implicated proteasomes in the generation of the antigenic peptides that are presented on major… 
Highly Cited
1994
Highly Cited
1994
cDNA cloning and interferon gamma down-regulation of proteasomal subunits X and Y.
Proteasomes are the proteolytic complex responsible for major histocompatibility complex (MHC) class I-restricted antigen… 
Highly Cited
1993
Highly Cited
1993
MHC-linked LMP gene products specifically alter peptidase activities of the proteasome
PROTEASOMES are highly conserved macromolecular structures which function as endopeptidases1–3. They are found in the cyto-plasm… 
Highly Cited
1993
Highly Cited
1993
PRE2, highly homologous to the human major histocompatibility complex-linked RING10 gene, codes for a yeast proteasome subunit necessary for chrymotryptic activity and degradation of ubiquitinated…
Highly Cited
1992
Highly Cited
1992
Proteasome subunits encoded in the MHC are not generally required for the processing of peptides bound by MHC class I molecules
ANTIGEN processing provides major histocompatibility complex (MHC) class I molecules with short peptides, which they selectively… 
Highly Cited
1991
Highly Cited
1991
Second proteasome-related gene in the human MHC class II region
ANTIGEN processing involves the generation of peptides from cytosolic proteins and their transport into the endoplasmic reticulum… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)