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Antigen Processing

Known as: Antigen Processings 
The process by which foreign molecules are taken up by antigen presenting cells, proteolytically cleaved, and displayed on the cell surface in… 
National Institutes of Health

Related topics

Related topics

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Antigen PresentationAntigen-Presenting CellsAntigensB-Cell Receptor Complex

Papers overview

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Highly Cited
2002
Highly Cited
2002
Proteasome, Transporter Associated with Antigen Processing, and Class I Genes in the Nurse Shark Ginglymostoma cirratum: Evidence for a Stable Class I Region and MHC Haplotype Lineages1
Cartilaginous fish (e.g., sharks) are derived from the oldest vertebrate ancestor having an adaptive immune system, and thus are… 
Highly Cited
2001
Highly Cited
2001
Lack of tumor recognition by hTERT peptide 540–548‐specific CD8+ T cells from melanoma patients reveals inefficient antigen processing
Telomerase is a ribonucleoprotein complex responsible for the maintenance of the length of the telomeres during cell division… 
Highly Cited
1997
Highly Cited
1997
The generation of MHC class I-associated peptides is only partially inhibited by proteasome inhibitors: involvement of nonproteasomal cytosolic proteases in antigen processing?
The proteasome is believed to participate in the generation of a large percentage of peptide ligands for MHC class I molecules… 
Highly Cited
1997
Highly Cited
1997
The effect of the proteasome inhibitor lactacystin on the presentation of transporter associated with antigen processing (TAP)-dependent and TAP-independent peptide epitopes by class I molecules.
Cells were treated with two proteolytic inhibitors, N-acetyl-leucyl-leucyl-norleucinal and lactacystin, the latter reported to be… 
Highly Cited
1994
Highly Cited
1994
Major Histocompatibility Complex–Encoded Antigen Processing Gene Polymorphism in IDDM
Susceptibility to insulin-dependent diabetes mellitus (IDDM) is greatly influenced by polymorphisms in the genes of the class II… 
Highly Cited
1994
Highly Cited
1994
Characterization of an incompletely assembled major histocompatibility class I molecule (H-2Kb) associated with unusually long peptides: implications for antigen processing and presentation.
We have identified two forms of a major histocompatibility complex (MHC) class I molecule, H-2Kb, distinguishable by specific… 
Highly Cited
1991
Highly Cited
1991
Reduction of disulfide bonds during antigen processing: evidence from a thiol-dependent insulin determinant
Previous studies have demonstrated that insulin, like other protein antigens, requires processing in metabolically active antigen… 
Highly Cited
1989
Highly Cited
1989
Turnover of Ia-peptide complexes is facilitated in viable antigen-presenting cells: biosynthetic turnover of Ia vs. peptide exchange.
Macrophages and B cells process antigens to produce antigenic peptides that associate with class II major histocompatibility… 
1988
1988
Protein synthesis in antigen processing.
Recent studies indicate that Ag pass through a chloroquine-sensitive intracellular pathway in accessory cells before they are… 
Highly Cited
1985
Highly Cited
1985
The molecular basis of the requirement for antigen processing of pigeon cytochrome c prior to T cell activation.
Antigen-induced activation of T lymphocytes that co-recognize Ia molecules has been shown to require an antigen-processing step… 
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