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Immuno-oncology approaches have entered clinical practice, with tremendous progress particularly in the field of T cell-engaging… Expand Ischemic stroke, which accounts for 75–80% of all strokes, is the predominant cause of morbidity and mortality worldwide. The… Expand mRNA technologies have the potential to transform areas of medicine, including the prophylaxis of infectious diseases. The… Expand ABSTRACT Introduction: Immune checkpoint inhibitors (ICIs) block cytotoxic T lymphocyte antigen 4 (CTLA-4) and programmed cell… Expand Gut microbiota is established during birth and evolves with age, mostly maintaining the commensal relationship with the host. A… Expand Triple Negative Breast Cancer (TNBC) is a highly heterogeneous subtype of breast cancer that lacks the expression of oestrogen… Expand Among the most promising approaches to activating therapeutic antitumour immunity is the blockade of immune checkpoints. Immune… Expand B and T lymphocytes are the mediators of immunity, but their function is under the control of dendritic cells. Dendritic cells in… Expand Approximately 10% of peripheral CD4+ cells and less than 1% of CD8+ cells in normal unimmunized adult mice express the IL-2… Expand Despite the differences in the antigens that they recognize and in the effector functions they carry out, B and T lymphocytes… Expand