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beta-Arrestins

Known as: beta Arrestins, beta-Arrestin, beta Arrestin 
Non-visual system arrestins that negatively regulate G-PROTEIN-COUPLED RECEPTORS (GPCRs) and may also function independently of GPCR signaling. They… 
National Institutes of Health

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Broader (1)

Antigens

Narrower (1)

Beta-Arrestin-1, human
In BloodProcess of secretionagonistsantagonists & inhibitors

Papers overview

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Review
2007
Review
2007
Beta-arrestin-biased ligands at seven-transmembrane receptors.
Seven-transmembrane receptors (7TMRs), the most common molecular targets of modern drug therapy, are critically regulated by beta… 
Highly Cited
2007
Highly Cited
2007
A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling.
For many years, beta-adrenergic receptor antagonists (beta-blockers or betaAR antagonists) have provided significant morbidity… 
Highly Cited
2005
Highly Cited
2005
An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior
Highly Cited
2005
Highly Cited
2005
Mast Cell Tryptase Controls Paracellular Permeability of the Intestine
Tight junctions between intestinal epithelial cells prevent ingress of luminal macromolecules and bacteria and protect against… 
Review
2002
Review
2002
Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and ß-arrestin proteins
Highly Cited
2001
Highly Cited
2001
beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking.
The two widely coexpressed isoforms of beta-arrestin (termed beta arrestin 1 and 2) are highly similar in amino acid sequence… 
Highly Cited
2001
Highly Cited
2001
Role of the Sphingosine-1-Phosphate Receptor EDG-1 in PDGF-Induced Cell Motility
EDG-1 is a heterotrimeric guanine nucleotide binding protein–coupled receptor (GPCR) for sphingosine-1-phosphate (SPP). Cell… 
Highly Cited
2000
Highly Cited
2000
β-Arrestin–Dependent Endocytosis of Proteinase-Activated Receptor 2 Is Required for Intracellular Targeting of Activated Erk1/2
Recently, a requirement for β-arrestin–mediated endocytosis in the activation of extracellular signal–regulated kinases 1 and 2… 
Highly Cited
1998
Highly Cited
1998
G Protein-coupled Receptors
Highly Cited
1998
Highly Cited
1998
Essential Role for G Protein-coupled Receptor Endocytosis in the Activation of Mitogen-activated Protein Kinase*
The classical paradigm for G protein-coupled receptor (GPCR) signal transduction involves the agonist-dependent interaction of… 
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