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A novel influenza A virus mitochondrial protein that induces cell death
It is proposed that PB1-F2 functions to kill host immune cells responding to influenza virus infection, and influenza viruses with targeted mutations that interfere with PB1/F2 expression induce less extensive apoptosis in human monocytic cells than those with intact PB1 -F2. Expand
The antigenic structure of the influenza virus A/PR/8/34 hemagglutinin (H1 subtype)
An operational antigenic map of the hemagglutinin of influenza virus A/PR/8/34 indicates the presence of five immunodominant antigenic regions exhibiting various degrees of operational linkage. Expand
XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation.
XBP1 coordinates diverse changes in cellular structure and function resulting in the characteristic phenotype of professional secretory cells, and upregulates genes encoding many secretory pathway components. Expand
Localization, quantitation, and in situ detection of specific peptide-MHC class I complexes using a monoclonal antibody.
A method for eliciting and identifying monoclonal antibodies specific for a particular peptide-MHC class I combination, which can identify antigen complexes with a limit of detection approaching that of T cells is described. Expand
Immunodominance in major histocompatibility complex class I-restricted T lymphocyte responses.
Little is known about how immunodominant and subdominant determinants are distinguished by the TCD8+ repertoire, or how (and why) immunodomination occurs, but new tools are available to address these questions. Expand
Rapid degradation of a large fraction of newly synthesized proteins by proteasomes
- U. Schubert, L. C. Antón, J. Gibbs, C. Norbury, J. Yewdell, J. Bennink
- Chemistry, Medicine
- 13 April 2000
It is shown that ubiquitinated DRiPs are formed from human immunodeficiency virus Gag polyprotein, a long-lived viral protein that serves as a source of antigenic peptides. Expand
CD1 recognition by mouse NK1+ T lymphocytes.
- A. Bendelac, O. Lantz, M. E. Quimby, J. Yewdell, J. Bennink, R. Brutkiewicz
- Biology, Medicine
- 12 May 1995
In mice, an entire subset of alpha beta thymocytes with a unique phenotype was found to be CD1-specific, providing evidence that CD1 has a general role in selecting and interacting with specialized alpha beta T cells. Expand
Herpes simplex virus turns off the TAP to evade host immunity
It is shown here that ICP47 binds to TAP and prevents peptide translocation into the endoplasmic reticulum. Expand
Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells
Findings indicate how NKp46-expressing NK cells may recognize target cells infected by influenza or parainfluenza without the decreased expression of target-cell MHC class I protein. Expand
Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia.
It is shown that expression of the viral accessory protein PB1-F2 enhances inflammation during primary viral infection of mice and increases both the frequency and severity of secondary bacterial pneumonia. Expand