• Publications
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Batf3 Deficiency Reveals a Critical Role for CD8α+ Dendritic Cells in Cytotoxic T Cell Immunity
TLDR
An important role is suggested for CD8α+ dendritic cells and cross-presentation in responses to viruses and in tumor rejection in Batf3–/– mice. Expand
Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation.
TLDR
Transcriptional and functional data revealed that monocyte-derived macrophages coordinate cardiac inflammation, while playing redundant but lesser roles in antigen sampling and efferocytosis, and the presence of multiple cardiac macrophage subsets, with different functions, origins, and strategies to regulate compartment size. Expand
Interleukin 1 is processed and released during apoptosis.
TLDR
The findings suggest that cell injury is an important physiologic stimulus for release of IL-1, and the nature of the injury profoundly affects the forms ofIL-1 that are released. Expand
Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10
TLDR
Macrophage production of TNF-alpha and IL-12 stimulates the release of IFN-gamma by NK cells and that IL-10 produced in response to hk-LM inhibits this response at the level of the macrophage and the NK cell. Expand
Binding of immunogenic peptides to Ia histocompatibility molecules
TLDR
A physical association of this peptide responsible for T-cell recognition of HEL is sought with purified, detergent-solubilized I–Ak molecules from B-hybridoma cells, which may explain the role of the Ia glycoproteins in cellular interactions. Expand
Antigen-presenting function of the macrophage.
  • E. Unanue
  • Biology, Medicine
  • Annual review of immunology
  • 1984
TLDR
The available information leads one to conclude that APC deficient in their capacity to internalize and process proteins will not be able to present them, and the macrophage is the candidate as the major APC involved in the recruitment and enlargement of clones T cells. Expand
Structural basis of peptide binding and presentation by the type I diabetes-associated MHC class II molecule of NOD mice.
TLDR
The crystal structure of I-Ag7, an integral component in murine type I diabetes development, is determined, and residues critical for T cell recognition were investigated with a panel of HEL(11-25)-restricted clones, which uncovered P1 anchor-dependent structural variations. Expand
MyD88-Dependent but Toll-Like Receptor 2-Independent Innate Immunity to Listeria: No Role for Either in Macrophage Listericidal Activity1
TLDR
It is demonstrated that although minor MyD88-independent responses to live Listeria do occur, these are insufficient for normal host defense, and it is concluded that the requirements for Toll-like receptor (TLR) signaling in vivo during early infection with Listersia monocytogenes are met. Expand
Type I Interferon Sensitizes Lymphocytes to Apoptosis and Reduces Resistance to Listeria Infection
TLDR
It is shown that mice deficient in the type I interferon (IFN) receptor were more resistant to Listeria infection and had less apoptotic lesions than wild-type counterparts, and treatment of resting splenic lymphocytes with recombinant IFN-alphaA enhanced their susceptibility to LLO-induced apoptosis. Expand
Antigen receptor engagement delivers a stop signal to migrating T lymphocytes.
TLDR
It is proposed that the stop signal is an early and essential event in T cell activation that also will play an important role in control of T cell migration. Expand
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