• Publications
  • Influence
A novel influenza A virus mitochondrial protein that induces cell death
TLDR
It is proposed that PB1-F2 functions to kill host immune cells responding to influenza virus infection, and influenza viruses with targeted mutations that interfere with PB1/F2 expression induce less extensive apoptosis in human monocytic cells than those with intact PB1 -F2.
Immunodominance in major histocompatibility complex class I-restricted T lymphocyte responses.
TLDR
Little is known about how immunodominant and subdominant determinants are distinguished by the TCD8+ repertoire, or how (and why) immunodomination occurs, but new tools are available to address these questions.
CD1 recognition by mouse NK1+ T lymphocytes.
TLDR
In mice, an entire subset of alpha beta thymocytes with a unique phenotype was found to be CD1-specific, providing evidence that CD1 has a general role in selecting and interacting with specialized alpha beta T cells.
Rapid degradation of a large fraction of newly synthesized proteins by proteasomes
TLDR
It is shown that ubiquitinated DRiPs are formed from human immunodeficiency virus Gag polyprotein, a long-lived viral protein that serves as a source of antigenic peptides.
Identification of poxvirus CD8+ T cell determinants to enable rational design and characterization of smallpox vaccines
TLDR
It is shown that the primary immunodominance hierarchy is greatly affected by the route of VACV infection and the poxvirus strain used, and modified vaccinia virus ankara, a candidate replacement smallpox vaccine, failed to induce responses to two of the defined determinants.
Visualizing priming of virus-specific CD8+ T cells by infected dendritic cells in vivo
TLDR
It was found that, following local infection, vaccinia virus infected macrophages and dendritic cells in draining lymph nodes, however, only the d endritic cells presented antigen to naïve CD8+ T cells, as determined by direct visualization of sectioned nodes by confocal microscopy.
Direct priming of antiviral CD8+ T cells in the peripheral interfollicular region of lymph nodes
TLDR
Intravital microscopy shows that after infection of mice with vaccinia virus or vesicular stomatitis virus, virions drained to the lymph node and infected cells residing just beneath the subcapsular sinus, and naive CD8+ T cells rapidly migrated to infected cells in the peripheral interfollicular region.
Hemagglutinin Receptor Binding Avidity Drives Influenza A Virus Antigenic Drift
TLDR
It is proposed that in response to variation in neutralizing antibody pressure between individuals, influenza A virus evolves by adjusting receptor binding avidity via amino acid substitutions throughout the hemagglutinin globular domain, many of which simultaneously alter antigenicity.
...
...