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A novel influenza A virus mitochondrial protein that induces cell death
While searching for alternative reading-frame peptides encoded by influenza A virus that are recognized by CD8+ T cells, we found an abundant immunogenic peptide encoded by the +1 reading frame ofExpand
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Localization, quantitation, and in situ detection of specific peptide-MHC class I complexes using a monoclonal antibody.
CD8+ T lymphocytes recognize antigens as short peptides bound to MHC class I molecules. Available methods cannot determine the number and distribution of these ligands on individual cells or detectExpand
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Immunodominance in major histocompatibility complex class I-restricted T lymphocyte responses.
Of the many thousands of peptides encoded by a complex foreign antigen that can potentially be presented to CD8+ T cells (TCD8+), only a small fraction induce measurable responses in association withExpand
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Rapid degradation of a large fraction of newly synthesized proteins by proteasomes
MHC class I molecules function to present peptides eight to ten residues long to the immune system. These peptides originate primarily from a cytosolic pool of proteins through the actions ofExpand
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CD1 recognition by mouse NK1+ T lymphocytes.
Rare major histocompatibility complex (MHC) class I-like CD1-specific T cells have been isolated from human blood, but it has not been determined whether these clones are part of a defined subset ofExpand
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Herpes simplex virus turns off the TAP to evade host immunity
MANY viruses have evolved mechanisms to avoid detection by the host immune system. Herpes simplex virus (HSV) expresses an immediate early protein, ICP47, which blocks presentation of viral peptidesExpand
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Identification of poxvirus CD8+ T cell determinants to enable rational design and characterization of smallpox vaccines
The large size of poxvirus genomes has stymied attempts to identify determinants recognized by CD8+ T cells and greatly impeded development of mouse smallpox vaccination models. Here, we use aExpand
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Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia.
Secondary bacterial pneumonia frequently claimed the lives of victims during the devastating 1918 influenza A virus pandemic. Little is known about the viral factors contributing to the lethality ofExpand
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Visualizing priming of virus-specific CD8+ T cells by infected dendritic cells in vivo
The rational design of vaccines that elicit CD8+ T cell responses requires knowledge of the identity of the antigen-presenting cell (APC), the location and time of presentation and the nature of theExpand
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Direct priming of antiviral CD8+ T cells in the peripheral interfollicular region of lymph nodes
It is uncertain how antiviral lymphocytes are activated in draining lymph nodes, the site where adaptive immune responses are initiated. Here, using intravital microscopy we show that after infectionExpand
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